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- W2060736945 endingPage "41" @default.
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- W2060736945 abstract "Drugs of abuse such as opioids and stimulants share a common dopaminergic reward pathway; however, in response to continual intermittent exposure to such drugs, there are neuronal alterations leading to changes in behavior. Regulators of G protein signaling (RGS) are proteins that negatively regulate G protein signaling and are expressed in brain areas important for the pharmacology of abused drugs. Moreover, the level of expression of several of these proteins is regulated by abused drugs. In this article, we discuss RGS proteins, their regulation by morphine and stimulants, and how altered levels of these proteins affect cell signaling to contribute to the pharmacology and behavioral consequence of abused drugs. Finally, we consider if RGS proteins represent viable targets for drug abuse medications." @default.
- W2060736945 created "2016-06-24" @default.
- W2060736945 creator A5016819654 @default.
- W2060736945 creator A5022375777 @default.
- W2060736945 date "2005-02-01" @default.
- W2060736945 modified "2023-10-14" @default.
- W2060736945 title "REGULATORs OF G PROTEIN SIGNALING & DRUGS OF ABUSE" @default.
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- W2060736945 doi "https://doi.org/10.1124/mi.5.1.7" @default.
- W2060736945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15734717" @default.
- W2060736945 hasPublicationYear "2005" @default.
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