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- W2060748049 abstract "The effect of substance P on catecholamine biosynthesis was examined using cultured bovine adrenal chromaffln cells as a model for the sympathoadrenergic system. Substance P markedly inhibited the formation of [14C]catecholamines from L-[14C]tyrosine stimulated by cholinergic agonist, but caused no significant effect on the biosynthesis stimulated by depolarizing agent. In addition, this inhibitory action was completely prevented by the addition of substance P antagonists. Under the conditions in which the inhibition of catecholamine biosynthesis was observed, substance P also inhibited the influx of extracellular 45Ca2+ into these cells, and this inhibitory action on Ca2+ influx was almost identical to that on the biosynthesis. These results provide evidence for a possible role of substance P as a putative neuromodulator in the sympathoadrenergic system." @default.
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- W2060748049 date "1993-03-01" @default.
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- W2060748049 title "Substance P inhibits catecholamine biosynthesis stimulated by carbamylcholine in cultured adrenal chromaffin cells" @default.
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- W2060748049 doi "https://doi.org/10.1016/0006-2952(93)90263-v" @default.
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