FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060764872> ?p ?o ?g. }

• W2060764872 endingPage "6879" @default.
• W2060764872 startingPage "6872" @default.
• W2060764872 abstract "Bovine milk lipoprotein lipase (LpL) catalyzes the hydrolysis of the water-soluble esters p-nitrophenyl acetate (PNPA) and p-nitrophenyl butyrate (PNPB). The same protein and same active site are involved in hydrolysis of water-soluble p-nitrophenyl esters and emulsified trioleoylglycerol since (a) trioleoylglycerol hydrolysis and PNPB hydrolysis activities coelute from the heparin-Sepharose affinity column used to purify LpL and (b) LpL-catalyzed hydrolyses of trioleoylglycerol and PNPB are inhibited to equal extents by phenylmethanesulfonyl fluoride. The effect of apolipoprotein C-II (apoC-II) on the LpL-catalyzed hydrolysis of PNPA and PNPB has been determined. ApoC-II inhibits hydrolysis of both esters, with a maximum extent of inhibition of 70-90%. Inhibition of the LpL-catalyzed hydrolysis of PNPB is specific for apoC-II, since apolipoproteins A-I, C-I, and C-III-2 have little effect on this reaction, and is partial noncompetitive in form. KI values for apoC-II inhibition of the LpL-catalyzed hydrolysis of PNPA and PNPB are in the range 0.26-0.83 microM. The effect of apoC-II on the temperature dependences of LpL-catalyzed hydrolysis of both esters and on NaCl inhibition of LpL-catalyzed PNPB hydrolysis is consistent with a change in rate-determining step with LpL and apoC-II interact. These results indicate not only that there is an interaction between apoC-II and LpL in aqueous solution in the absence of a lipid interface but also that this interaction conformationally modulates the active site of the enzyme." @default.
• W2060764872 created "2016-06-24" @default.
• W2060764872 creator A5002758115 @default.
• W2060764872 creator A5013836679 @default.
• W2060764872 creator A5029124172 @default.
• W2060764872 creator A5081851324 @default.
• W2060764872 date "1982-12-01" @default.
• W2060764872 modified "2023-09-25" @default.
• W2060764872 title "Lipoprotein lipase-catalyzed hydrolysis of water-soluble p-nitrophenyl esters. Inhibition by apolipoprotein C-II" @default.
• W2060764872 cites W1498042732 @default.
• W2060764872 cites W1506095488 @default.
• W2060764872 cites W1525055187 @default.
• W2060764872 cites W1548991782 @default.
• W2060764872 cites W1582357284 @default.
• W2060764872 cites W1599816762 @default.
• W2060764872 cites W1720895391 @default.
• W2060764872 cites W1775749144 @default.
• W2060764872 cites W1969954912 @default.
• W2060764872 cites W1996450421 @default.
• W2060764872 cites W1997542488 @default.
• W2060764872 cites W2001609219 @default.
• W2060764872 cites W2005023114 @default.
• W2060764872 cites W2007611676 @default.
• W2060764872 cites W2010475848 @default.
• W2060764872 cites W2018301906 @default.
• W2060764872 cites W2020686577 @default.
• W2060764872 cites W2032475772 @default.
• W2060764872 cites W2034099538 @default.
• W2060764872 cites W2069717269 @default.
• W2060764872 cites W2071181652 @default.
• W2060764872 cites W2072054150 @default.
• W2060764872 cites W2080671252 @default.
• W2060764872 cites W2082878166 @default.
• W2060764872 cites W2082899795 @default.
• W2060764872 cites W2088616240 @default.
• W2060764872 cites W2092356081 @default.
• W2060764872 cites W2092359033 @default.
• W2060764872 cites W2096096102 @default.
• W2060764872 cites W2129725267 @default.
• W2060764872 cites W2220000844 @default.
• W2060764872 cites W2280745535 @default.
• W2060764872 cites W2327887667 @default.
• W2060764872 doi "https://doi.org/10.1021/bi00269a038" @default.
• W2060764872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7159570" @default.
• W2060764872 hasPublicationYear "1982" @default.
• W2060764872 type Work @default.
• W2060764872 sameAs 2060764872 @default.
• W2060764872 citedByCount "79" @default.
• W2060764872 countsByYear W20607648722012 @default.
• W2060764872 countsByYear W20607648722013 @default.
• W2060764872 countsByYear W20607648722014 @default.
• W2060764872 countsByYear W20607648722015 @default.
• W2060764872 countsByYear W20607648722016 @default.
• W2060764872 countsByYear W20607648722017 @default.
• W2060764872 countsByYear W20607648722018 @default.
• W2060764872 countsByYear W20607648722019 @default.
• W2060764872 countsByYear W20607648722020 @default.
• W2060764872 countsByYear W20607648722021 @default.
• W2060764872 countsByYear W20607648722022 @default.
• W2060764872 countsByYear W20607648722023 @default.
• W2060764872 crossrefType "journal-article" @default.
• W2060764872 hasAuthorship W2060764872A5002758115 @default.
• W2060764872 hasAuthorship W2060764872A5013836679 @default.
• W2060764872 hasAuthorship W2060764872A5029124172 @default.
• W2060764872 hasAuthorship W2060764872A5081851324 @default.
• W2060764872 hasConcept C161790260 @default.
• W2060764872 hasConcept C178790620 @default.
• W2060764872 hasConcept C181199279 @default.
• W2060764872 hasConcept C185592680 @default.
• W2060764872 hasConcept C2779697368 @default.
• W2060764872 hasConcept C43617362 @default.
• W2060764872 hasConcept C55493867 @default.
• W2060764872 hasConcept C71240020 @default.
• W2060764872 hasConcept C94412978 @default.
• W2060764872 hasConcept C94879076 @default.
• W2060764872 hasConceptScore W2060764872C161790260 @default.
• W2060764872 hasConceptScore W2060764872C178790620 @default.
• W2060764872 hasConceptScore W2060764872C181199279 @default.
• W2060764872 hasConceptScore W2060764872C185592680 @default.
• W2060764872 hasConceptScore W2060764872C2779697368 @default.
• W2060764872 hasConceptScore W2060764872C43617362 @default.
• W2060764872 hasConceptScore W2060764872C55493867 @default.
• W2060764872 hasConceptScore W2060764872C71240020 @default.
• W2060764872 hasConceptScore W2060764872C94412978 @default.
• W2060764872 hasConceptScore W2060764872C94879076 @default.
• W2060764872 hasIssue "26" @default.
• W2060764872 hasLocation W20607648721 @default.
• W2060764872 hasLocation W20607648722 @default.
• W2060764872 hasOpenAccess W2060764872 @default.
• W2060764872 hasPrimaryLocation W20607648721 @default.
• W2060764872 hasRelatedWork W2003173719 @default.
• W2060764872 hasRelatedWork W2077760150 @default.
• W2060764872 hasRelatedWork W2083383372 @default.
• W2060764872 hasRelatedWork W2089545573 @default.
• W2060764872 hasRelatedWork W2110923675 @default.
• W2060764872 hasRelatedWork W2171663702 @default.
• W2060764872 hasRelatedWork W2949450553 @default.
• W2060764872 hasRelatedWork W2951316381 @default.

• next