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• W2060771859 abstract "Abstract OTR4120, which belongs to a family of heparan sulfate‐mimetic polymers, promotes tissue repair when injected locally in doses of a few micrograms. As OTR4120 is a sulfated polysaccharide, we investigated its possible role on the coagulation cascade. We used both in vitro and in vivo assays. Increases in clotting times (thrombin time, prothrombin time, and activated partial thromboplastin time) occurred with OTR4120 in doses at least 10 times lower than heparin. OTR4120 dose‐dependently inhibited the biological activity of thrombin and bound thrombin with an affinity of 14 ± 2 n M . SDS‐PAGE showed that OTR4120 induced the formation of covalently linked complexes between antithrombin III or heparin cofactor II and thrombin. OTR4120 induced anticoagulant effects, and antithrombin activity was greatest 90 min after intraperitoneal injection. No bleeding or significant platelet count changes occurred with doses smaller than 55 mg/kg. Interestingly, orally administered OTR4120 crossed the gastrointestinal barrier and, in a dose of 70 mg/kg, induced significant ex vivo antithrombotic activity in the bloodstream. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007" @default.
• W2060771859 created "2016-06-24" @default.
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• W2060771859 date "2007-06-21" @default.
• W2060771859 modified "2023-10-14" @default.
• W2060771859 title "Effects on coagulation of a synthetic heparan mimetic given intraperitoneally or orally" @default.
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• W2060771859 doi "https://doi.org/10.1002/jbm.a.31385" @default.
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