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- W2060772907 abstract "Once thought to be a part of the ‘dark matter’ of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian transcriptome. LncRNAs are a novel class of mRNA-like transcripts which, despite no known protein-coding potential, demonstrate a wide range of structural and functional roles in cellular biology. However, the magnitude of the contribution of lncRNA expression to normal human tissues and cancers has not been investigated in a comprehensive manner. In this study, we compiled 272 human serial analysis of gene expression (SAGE) libraries to delineate lncRNA transcription patterns across a broad spectrum of normal human tissues and cancers. Using a novel lncRNA discovery pipeline we parsed over 24 million SAGE tags and report lncRNA expression profiles across a panel of 26 different normal human tissues and 19 human cancers. Our findings show extensive, tissue-specific lncRNA expression in normal tissues and highly aberrant lncRNA expression in human cancers. Here, we present a first generation atlas for lncRNA profiling in cancer." @default.
- W2060772907 created "2016-06-24" @default.
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- W2060772907 date "2011-10-03" @default.
- W2060772907 modified "2023-10-02" @default.
- W2060772907 title "Human Cancer Long Non-Coding RNA Transcriptomes" @default.
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- W2060772907 doi "https://doi.org/10.1371/journal.pone.0025915" @default.
- W2060772907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3185064" @default.
- W2060772907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21991387" @default.
- W2060772907 hasPublicationYear "2011" @default.
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