FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060778439> ?p ?o ?g. }

• W2060778439 endingPage "324" @default.
• W2060778439 startingPage "317" @default.
• W2060778439 abstract "Background The adrenal cortex may contain progenitor cells useful for tissue regeneration. Currently there are no established methods to isolate these cells. Material and Methods Murine adrenal cells were sorted into a Nile-red-bright (NRbright) and a Nile-red-dim (NRdim) population of cells according to their degree of cholesterol content revealed by Nile red fluorescence. The cells were transplanted under the renal capsule to determine their ability for regeneration. Results The NRbright cells contained an abundance of lipid droplets, whereas the NRdim cells contained little. The NRbright cells expressed Sf1 and the more differentiated adrenal cortical genes, including Cyp11a1, Cyp11b1, and Cyp11b2, whereas the NRdim cells expressed Sf1 but not the more differentiated adrenal cortical genes. After 56 d of implantation in unilateral adrenalectomized mice, the NRdim cells expressed Sf1 and the more differentiated adrenal cortical genes, whereas the NRbright cells ceased to express Sf1 as well as the more differentiated adrenal cortical genes. NRdim cells also proliferated in the presence of basic fibroblast growth factor. Conclusions The population of NRdim cells contained adrenal cortical progenitor cells that can proliferate and give rise to differentiated daughter cells. These cells may be useful for adrenal cortical regeneration. The adrenal cortex may contain progenitor cells useful for tissue regeneration. Currently there are no established methods to isolate these cells. Murine adrenal cells were sorted into a Nile-red-bright (NRbright) and a Nile-red-dim (NRdim) population of cells according to their degree of cholesterol content revealed by Nile red fluorescence. The cells were transplanted under the renal capsule to determine their ability for regeneration. The NRbright cells contained an abundance of lipid droplets, whereas the NRdim cells contained little. The NRbright cells expressed Sf1 and the more differentiated adrenal cortical genes, including Cyp11a1, Cyp11b1, and Cyp11b2, whereas the NRdim cells expressed Sf1 but not the more differentiated adrenal cortical genes. After 56 d of implantation in unilateral adrenalectomized mice, the NRdim cells expressed Sf1 and the more differentiated adrenal cortical genes, whereas the NRbright cells ceased to express Sf1 as well as the more differentiated adrenal cortical genes. NRdim cells also proliferated in the presence of basic fibroblast growth factor. The population of NRdim cells contained adrenal cortical progenitor cells that can proliferate and give rise to differentiated daughter cells. These cells may be useful for adrenal cortical regeneration." @default.
• W2060778439 created "2016-06-24" @default.
• W2060778439 creator A5007429540 @default.
• W2060778439 creator A5027041543 @default.
• W2060778439 creator A5064384118 @default.
• W2060778439 creator A5080742187 @default.
• W2060778439 date "2009-10-01" @default.
• W2060778439 modified "2023-10-11" @default.
• W2060778439 title "Transplantation of Adrenal Cortical Progenitor Cells Enriched by Nile Red" @default.
• W2060778439 cites W1978916626 @default.
• W2060778439 cites W1984099131 @default.
• W2060778439 cites W1998970590 @default.
• W2060778439 cites W2002104786 @default.
• W2060778439 cites W2004245707 @default.
• W2060778439 cites W2004829788 @default.
• W2060778439 cites W2005265138 @default.
• W2060778439 cites W2009549069 @default.
• W2060778439 cites W2027135261 @default.
• W2060778439 cites W2027833688 @default.
• W2060778439 cites W2030773389 @default.
• W2060778439 cites W2031092540 @default.
• W2060778439 cites W2037202282 @default.
• W2060778439 cites W2049076869 @default.
• W2060778439 cites W2067814358 @default.
• W2060778439 cites W2076820575 @default.
• W2060778439 cites W2081511864 @default.
• W2060778439 cites W2082886788 @default.
• W2060778439 cites W2101927159 @default.
• W2060778439 cites W2104049337 @default.
• W2060778439 cites W2109960702 @default.
• W2060778439 cites W2110985070 @default.
• W2060778439 cites W2116240577 @default.
• W2060778439 cites W2134579258 @default.
• W2060778439 cites W2149197499 @default.
• W2060778439 cites W2293292650 @default.
• W2060778439 cites W4242290559 @default.
• W2060778439 cites W4242629244 @default.
• W2060778439 cites W4243051625 @default.
• W2060778439 cites W4253645951 @default.
• W2060778439 doi "https://doi.org/10.1016/j.jss.2009.04.021" @default.
• W2060778439 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2749914" @default.
• W2060778439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19592014" @default.
• W2060778439 hasPublicationYear "2009" @default.
• W2060778439 type Work @default.
• W2060778439 sameAs 2060778439 @default.
• W2060778439 citedByCount "12" @default.
• W2060778439 countsByYear W20607784392012 @default.
• W2060778439 countsByYear W20607784392017 @default.
• W2060778439 countsByYear W20607784392018 @default.
• W2060778439 countsByYear W20607784392021 @default.
• W2060778439 crossrefType "journal-article" @default.
• W2060778439 hasAuthorship W2060778439A5007429540 @default.
• W2060778439 hasAuthorship W2060778439A5027041543 @default.
• W2060778439 hasAuthorship W2060778439A5064384118 @default.
• W2060778439 hasAuthorship W2060778439A5080742187 @default.
• W2060778439 hasBestOaLocation W20607784392 @default.
• W2060778439 hasConcept C126322002 @default.
• W2060778439 hasConcept C134018914 @default.
• W2060778439 hasConcept C201750760 @default.
• W2060778439 hasConcept C2777977426 @default.
• W2060778439 hasConcept C28328180 @default.
• W2060778439 hasConcept C2908647359 @default.
• W2060778439 hasConcept C71924100 @default.
• W2060778439 hasConcept C86803240 @default.
• W2060778439 hasConcept C95444343 @default.
• W2060778439 hasConcept C99454951 @default.
• W2060778439 hasConceptScore W2060778439C126322002 @default.
• W2060778439 hasConceptScore W2060778439C134018914 @default.
• W2060778439 hasConceptScore W2060778439C201750760 @default.
• W2060778439 hasConceptScore W2060778439C2777977426 @default.
• W2060778439 hasConceptScore W2060778439C28328180 @default.
• W2060778439 hasConceptScore W2060778439C2908647359 @default.
• W2060778439 hasConceptScore W2060778439C71924100 @default.
• W2060778439 hasConceptScore W2060778439C86803240 @default.
• W2060778439 hasConceptScore W2060778439C95444343 @default.
• W2060778439 hasConceptScore W2060778439C99454951 @default.
• W2060778439 hasIssue "2" @default.
• W2060778439 hasLocation W20607784391 @default.
• W2060778439 hasLocation W20607784392 @default.
• W2060778439 hasLocation W20607784393 @default.
• W2060778439 hasLocation W20607784394 @default.
• W2060778439 hasOpenAccess W2060778439 @default.
• W2060778439 hasPrimaryLocation W20607784391 @default.
• W2060778439 hasRelatedWork W1966504330 @default.
• W2060778439 hasRelatedWork W1972779667 @default.
• W2060778439 hasRelatedWork W1979139803 @default.
• W2060778439 hasRelatedWork W1984079239 @default.
• W2060778439 hasRelatedWork W1991560548 @default.
• W2060778439 hasRelatedWork W2037631372 @default.
• W2060778439 hasRelatedWork W2040058909 @default.
• W2060778439 hasRelatedWork W2069416673 @default.
• W2060778439 hasRelatedWork W2132898409 @default.
• W2060778439 hasRelatedWork W2748952813 @default.
• W2060778439 hasVolume "156" @default.
• W2060778439 isParatext "false" @default.
• W2060778439 isRetracted "false" @default.
• W2060778439 magId "2060778439" @default.
• W2060778439 workType "article" @default.