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• W2060794085 abstract "Quartz crystal microbalance (QCM) biosensor integrated in a flow injection analysis (FIA) system was used for the real-time investigation of the interaction between human TNF-α (hTNF-α) and its monoclonal antibodies (mAbs). Biologically active hTNF-α trimer was immobilized on the gold electrodes of the piezoelectric crystals and the binding interactions of the two immobilized antigen with two anti-hTNF-α monoclonal antibodies (Z8 and Z12) were followed as changes in the resonant frequency of the modified crystals. The resultant sensorgrams were rapidly analyzed by using an in-house kinetic analysis software based on genetic algorithm (GA) to derive both the kinetic rate constants (kass and kdiss) and equilibrium dissociation constant (KD) for antigen–antibody interactions. For the interactions, KD were 2.31×10−7 and 5.42×10−7 M for Z8 and Z12, respectively. The generally good agreement found between biosensor data and the affinities known from conventional equilibrium enzyme-linked immunosorbent assay (ELISA) validates this analytical method. The study shows the potential usefulness of QCM biosensor technology for biomolecular interaction analysis." @default.
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• W2060794085 date "2004-05-01" @default.
• W2060794085 modified "2023-10-12" @default.
• W2060794085 title "Quartz crystal biosensor for real-time kinetic analysis of interaction between human TNF-α and monoclonal antibodies" @default.
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• W2060794085 doi "https://doi.org/10.1016/j.snb.2003.12.010" @default.
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