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• W2060804947 abstract "To evaluate if there is a performance difference in the combined screening for trisomy 21 between the double tests performed before and after 10 + 0 weeks of gestation.The study included all 97 trisomy 21 cases from January 2004 to December 2007, in a screening program where the double test was measured in week 8 + 0 to 13 + 6 and the nuchal translucency in week 11 + 3 to 13 + 6.As many as 87 of the 97 cases were diagnosed in the screening program (detection rate = 90%). Among the 53 cases having the double test taken before 10 + 0 weeks, no cases were missed [detection rate (DR) = 100%, CI = 0.94-1.00] and among the 44 having the double test taken after 10 + 0 weeks, 10 cases were missed (DR = 77%, CI = 0.65-0.90). This difference in DR was highly significant (P = 0.0009). No difference was observed between false positive rates or median maternal age of the two groups.A significantly higher DR was obtained when the double test was taken early in pregnancy (<10 + 0 weeks), than when it was taken later (>or=10 + 0 weeks). The results could not be explained by a difference in either the false positive rate or the maternal age between the two groups." @default.
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• W2060804947 date "2008-09-01" @default.
• W2060804947 modified "2023-09-27" @default.
• W2060804947 title "Improved performance of first-trimester combined screening for trisomy 21 with the double test taken before a gestational age of 10 weeks" @default.
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• W2060804947 doi "https://doi.org/10.1002/pd.2057" @default.
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