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• W2060804963 startingPage "158" @default.
• W2060804963 abstract "BXSB male mice serve as one of several murine models of human systemic lupus erythematosus. T-cell abnormalities in these mice involve decreased production of and responsiveness interleukin 2 (IL-2) and are age-related. The studies presented here investigated the mechanism of these T-cell defects. The results suggest that excessive suppressor-T-cell activity as well as soluble inhibitors of IL-2 production and activity, including PGE, are not responsible for the low levels of IL-2 observed in culture supernatants of Con A-stimulated lymphocytes from old (3-6 months) BXSB male mice. Supplementation of Con A-stimulated lymphocyte cultures from BXSB male mice with human IL-1 or normal murine accessory cells did not augment IL-2 production. Reduced proliferative responses were observed in bulk cultures of Con A- or alloantigen-stimulated old BXSB male lymphocytes, which were not enhanced by exogenous IL-2. Limiting dilution analysis revealed reduced frequencies of Con A- and alloantigen-inducible IL-2-reactive T cells in these mice. These results suggest intrinsic defects in the ability of T cells from old BXSB male mice to be activated to produce and respond to IL-2." @default.
• W2060804963 created "2016-06-24" @default.
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• W2060804963 date "1987-06-01" @default.
• W2060804963 modified "2023-09-23" @default.
• W2060804963 title "Production of and responsiveness to interleukin 2 in autoimmune BXSB mice" @default.
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• W2060804963 doi "https://doi.org/10.1016/0008-8749(87)90276-0" @default.
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