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- W2060804987 abstract "Abstract The diastereoselective synthesis of 2,3-methanophenylalanine methyl esters (5) has been achieved in 58% yield. The preparation of the dehydropeptides (1, R = Me; 2, R = H) and the cyclopropylpeptides (3, R = Me; 4, R = H) possessing good binding affinities for the CCK-A and CCK-B receptors is described. Conformational studies of the dipeptide esters 1 and 3 indicated the presence of a β-turn within the peptide backbone, although there was no preference in type. The Phe and Trp moieties, however, did prefer to be situated on the same side of the peptide turn which is favourable for receptor binding." @default.
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- W2060804987 date "1996-02-01" @default.
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- W2060804987 title "Preparation of Dipeptoid Mimetics for the Tetrapeptide Cholecystokinin, CCK(30–33)" @default.
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- W2060804987 doi "https://doi.org/10.1111/j.2042-7158.1996.tb07120.x" @default.
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