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- W2060805028 abstract "Abstract The meso- and (±)-isomers of dimethylmyleran (DMM) have been synthesised and their chemical reactivity towards selected nucleophiles has been investigated. Both isomers react in vitro by hydrolysis to give 2,5-dimethyltetrahydrofuran and with the thiol groups of cysteine, cysteine ethyl ester and glutathione forming 2,5-dimethyltetrahydrothiophene. As each of these cyclic compounds exists in the cis- and trans-configurations, their production in stereochemically quantitative yields from meso- and (±)-dimethylmyleran respectively, indicates that both isomers react by a bimolecular process and not a unimolecular one as has been generally accepted. A comparison of the activity of the isomers with that of Myleran on anti-fertility action, neutrophildepressant activity and effect on the weight response suggests that these esters could exert their biological actions in vivo by the same mechanism." @default.
- W2060805028 created "2016-06-24" @default.
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- W2060805028 date "1973-01-01" @default.
- W2060805028 modified "2023-09-23" @default.
- W2060805028 title "Studies with alkylating esters VI. The chemical and biological activities of the isomers of dimethylmyleran" @default.
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- W2060805028 doi "https://doi.org/10.1016/0009-2797(73)90085-9" @default.
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