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- W2060811660 abstract "The synthesis of 15 methyl or unsubstituted 1,2,3-triazoles, 1,2,4-triazoles, and tetrazoles additionally substituted with a 1-azabicyclo[2.2.2]octan-3-yl group is described. The potency and efficacy of these compounds as muscarinic ligands were determined in radioligand binding assays using [3H]oxotremorine and [3H]quinuclidinyl benzilate. Potency and efficacy were found in compounds in which the azole moiety was attached to the azabicyclic ring either through a carbon atom or a nitrogen atom. Electrostatic potential maps of both the C-linked and the novel N-linked series of compounds were calculated. A relationship between position and depth of the electrostatic minima relative to the azabicyclic ring and the potency and efficacy of the compounds was determined." @default.
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- W2060811660 date "1992-04-01" @default.
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- W2060811660 title "Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives" @default.
- W2060811660 doi "https://doi.org/10.1021/jm00085a016" @default.
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