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- W2060813805 abstract "Despite the demonstration of multiple biologic effects of estrogen that may protect against atherosclerosis and its ischemic manifestations, many women are reluctant to take chronic estrogen therapy because of fear of endometrial and breast cancer, and because of adverse effects including resumption of periodic vaginal bleeding. Accordingly, identification of alternative therapies that might replicate the biologic effects of estrogen but are devoid of these unwanted side effects of prolonged estrogen therapy would be of a considerable interest to women at risk for atherosclerosis. Raloxifene hydrochloride is a compound derived from a benzothiophene series of antiestrogens and is classified as a selective estrogen receptor modulator. 1 Draper M.W Flowers D.E Neild J.A Huster W.J Zer be R.L Antiestrogenic properties of raloxifene. Pharmacology. 1995; 50: 209-217 Crossref PubMed Scopus (43) Google Scholar In postmenopausal women, raloxifene appears to exert an estrogen-like effect on lipoprotein metabolism with reduction in low-density lipoprotein cholesterol and lipoprotein(a) levels, but does not increase high-density lipoprotein cholesterol levels. 2 Walsh B.W Kuller L.H Wild R.A Paul S Farmer M Lawrence J.B Shah A.S Anderson P.W Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women. JAMA. 1998; 279: 1445-1451 Crossref PubMed Scopus (665) Google Scholar Because raloxifene has estrogenic effects on atherogenic lipoproteins, this compound may reduce vascular inflammation with antiatherogenic consequences. Such demonstration would have considerable implications for cardioprotection of postmenopausal women, potentially preferable to estrogen therapy for chronic use because of the apparent absence of carcinogenic effects of raloxifene on the breast and uterus. This study examined whether raloxifene reduces serum levels of markers of inflammation in postmenopausal women compared with responses to conjugated equine estrogens (CEE) hormone therapy." @default.
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- W2060813805 date "2000-08-01" @default.
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- W2060813805 title "Effects of estrogen and the selective estrogen receptor modulator raloxifene on markers of inflammation in postmenopausal women" @default.
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- W2060813805 doi "https://doi.org/10.1016/s0002-9149(00)01116-4" @default.
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