FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060813897> ?p ?o ?g. }

• W2060813897 endingPage "41" @default.
• W2060813897 startingPage "29" @default.
• W2060813897 abstract "Analysis of base composition has proven important for functional gene analysis. By comparing base composition and codon usage between two specific human gene families we were able to show a highly conserved nucleotide distribution among the members of one gene family and a significant difference between the two families. The two groups selected for analysis were the human factor H gene family, which represents six secreted human plasma proteins with functions in immune defense, and a class of four human zinc finger proteins, termed early growth response (EGR) proteins, which represent DNA-binding transcription factors. The nucleotide distribution of each gene family is distinct: members of the factor H gene family represent AT-rich genes, displaying an overall AT nucleotide content of 62.8% and a particular preference for A nucleotides (33.9%). In contrast, the EGR genes are GC-rich (55.9%) and C nucleotides are used in 31.2%. This nucleotide difference affects codon usage among synonymous codons and is considered of biological significance, as it affects DNA stability. The codon preference is particularly high at codon position 3, where each family selects for codons which have the preferred nucleotide at this silent third position. At position 3, A nucleotides are preferred by factor H genes in 36.3% of the 2,503 codons analyzed, compared to 10% of the 1,876 codons analyzed for the EGR family. In contrast, C nucleotides are used by the EGR family in 48.1%, compared to 16% of the triplets used by the factor H gene family. This comparison of two human gene families shows that nucleotide distribution and codon usage is not uniform within the human organism and the described differences most likely represent selection constraints between the polymorphic factor H and highly conserved EGR genes." @default.
• W2060813897 created "2016-06-24" @default.
• W2060813897 creator A5021132451 @default.
• W2060813897 creator A5067381987 @default.
• W2060813897 creator A5074615051 @default.
• W2060813897 date "2000-01-01" @default.
• W2060813897 modified "2023-10-14" @default.
• W2060813897 title "Two Human Gene Families Display Preferences for Different Nucleotides and Have Distinct Codon Usage Patterns" @default.
• W2060813897 cites W1534759813 @default.
• W2060813897 cites W1567881416 @default.
• W2060813897 cites W1580855998 @default.
• W2060813897 cites W1589324068 @default.
• W2060813897 cites W1594677530 @default.
• W2060813897 cites W1603411458 @default.
• W2060813897 cites W1615621128 @default.
• W2060813897 cites W1675921820 @default.
• W2060813897 cites W1945308210 @default.
• W2060813897 cites W1963730637 @default.
• W2060813897 cites W1971604501 @default.
• W2060813897 cites W1971889381 @default.
• W2060813897 cites W1977566832 @default.
• W2060813897 cites W1984767179 @default.
• W2060813897 cites W1985473616 @default.
• W2060813897 cites W1992404702 @default.
• W2060813897 cites W1993004730 @default.
• W2060813897 cites W2002830521 @default.
• W2060813897 cites W2005969056 @default.
• W2060813897 cites W2012456489 @default.
• W2060813897 cites W2012911917 @default.
• W2060813897 cites W2015242897 @default.
• W2060813897 cites W2018662284 @default.
• W2060813897 cites W2019035528 @default.
• W2060813897 cites W2030034646 @default.
• W2060813897 cites W2030871047 @default.
• W2060813897 cites W2033145713 @default.
• W2060813897 cites W2035945428 @default.
• W2060813897 cites W2046125258 @default.
• W2060813897 cites W2046291479 @default.
• W2060813897 cites W2052204842 @default.
• W2060813897 cites W2054158885 @default.
• W2060813897 cites W2061186144 @default.
• W2060813897 cites W2065853381 @default.
• W2060813897 cites W2072417552 @default.
• W2060813897 cites W2074459836 @default.
• W2060813897 cites W2078157295 @default.
• W2060813897 cites W2081020710 @default.
• W2060813897 cites W2082640307 @default.
• W2060813897 cites W2084888659 @default.
• W2060813897 cites W2089966039 @default.
• W2060813897 cites W2091683537 @default.
• W2060813897 cites W2095389787 @default.
• W2060813897 cites W2099528191 @default.
• W2060813897 cites W2124502341 @default.
• W2060813897 cites W2133335149 @default.
• W2060813897 cites W2133885414 @default.
• W2060813897 cites W2138721124 @default.
• W2060813897 cites W2148740955 @default.
• W2060813897 cites W2155580358 @default.
• W2060813897 cites W2157848631 @default.
• W2060813897 cites W2164618276 @default.
• W2060813897 cites W2167604659 @default.
• W2060813897 cites W2429721485 @default.
• W2060813897 doi "https://doi.org/10.1159/000019122" @default.
• W2060813897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10686481" @default.
• W2060813897 hasPublicationYear "2000" @default.
• W2060813897 type Work @default.
• W2060813897 sameAs 2060813897 @default.
• W2060813897 citedByCount "2" @default.
• W2060813897 crossrefType "journal-article" @default.
• W2060813897 hasAuthorship W2060813897A5021132451 @default.
• W2060813897 hasAuthorship W2060813897A5067381987 @default.
• W2060813897 hasAuthorship W2060813897A5074615051 @default.
• W2060813897 hasConcept C104317684 @default.
• W2060813897 hasConcept C141231307 @default.
• W2060813897 hasConcept C150194340 @default.
• W2060813897 hasConcept C512185932 @default.
• W2060813897 hasConcept C54355233 @default.
• W2060813897 hasConcept C5911399 @default.
• W2060813897 hasConcept C86803240 @default.
• W2060813897 hasConcept C87253356 @default.
• W2060813897 hasConceptScore W2060813897C104317684 @default.
• W2060813897 hasConceptScore W2060813897C141231307 @default.
• W2060813897 hasConceptScore W2060813897C150194340 @default.
• W2060813897 hasConceptScore W2060813897C512185932 @default.
• W2060813897 hasConceptScore W2060813897C54355233 @default.
• W2060813897 hasConceptScore W2060813897C5911399 @default.
• W2060813897 hasConceptScore W2060813897C86803240 @default.
• W2060813897 hasConceptScore W2060813897C87253356 @default.
• W2060813897 hasIssue "1" @default.
• W2060813897 hasLocation W20608138971 @default.
• W2060813897 hasOpenAccess W2060813897 @default.
• W2060813897 hasPrimaryLocation W20608138971 @default.
• W2060813897 hasRelatedWork W1565897669 @default.
• W2060813897 hasRelatedWork W2007559212 @default.
• W2060813897 hasRelatedWork W2013108791 @default.
• W2060813897 hasRelatedWork W2060450464 @default.
• W2060813897 hasRelatedWork W2132060660 @default.
• W2060813897 hasRelatedWork W2143024320 @default.

• next