FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060819997> ?p ?o ?g. }

• W2060819997 endingPage "200" @default.
• W2060819997 startingPage "191" @default.
• W2060819997 abstract "The enzyme RedP is thought to initiate the biosynthesis of the undecylpyrolle component of the antibiotic undecylprodiginine produced by Streptomyces coelicolor. RedP has homology to FabH, which initiates fatty acid biosynthesis by condensing the appropriate acyl-CoA starter unit with malonyl ACP. We have generated a redP-deletion mutant of S. coelicolor M511 (SJM1) and shown that it produces reduced levels of prodiginines and two new analogs, methylundecylprodiginine and methyldodecylprodiginine. Incorporation studies with perdeuterated valine were consistent with these being generated using methylbutyryl-CoA and isobutyryl-CoA as starter units, respectively. Plasmid-based expression of a streptomycete fabH in the SJM1 mutant led to restoration of overall prodiginine titers but the same overall ratio of undecylprodiginines and novel prodiginines. Thus, the redP FabH can be replaced by FabH enzymes with different substrate specificities and provides a method for generating novel prodiginines." @default.
• W2060819997 created "2016-06-24" @default.
• W2060819997 creator A5009925574 @default.
• W2060819997 creator A5029616013 @default.
• W2060819997 creator A5048925702 @default.
• W2060819997 date "2005-02-01" @default.
• W2060819997 modified "2023-10-16" @default.
• W2060819997 title "Production of Branched-Chain Alkylprodiginines in S. coelicolor by Replacement of the 3-Ketoacyl ACP Synthase III Initiation Enzyme, RedP" @default.
• W2060819997 cites W1493623656 @default.
• W2060819997 cites W1496011245 @default.
• W2060819997 cites W1509879853 @default.
• W2060819997 cites W1590673420 @default.
• W2060819997 cites W1595451534 @default.
• W2060819997 cites W1896660825 @default.
• W2060819997 cites W1965972464 @default.
• W2060819997 cites W1981683389 @default.
• W2060819997 cites W1983112514 @default.
• W2060819997 cites W1985932094 @default.
• W2060819997 cites W1991755174 @default.
• W2060819997 cites W1997029030 @default.
• W2060819997 cites W2007903524 @default.
• W2060819997 cites W2012960603 @default.
• W2060819997 cites W2014197955 @default.
• W2060819997 cites W2015900502 @default.
• W2060819997 cites W2018978400 @default.
• W2060819997 cites W2023950913 @default.
• W2060819997 cites W2031541469 @default.
• W2060819997 cites W2049546789 @default.
• W2060819997 cites W2061061830 @default.
• W2060819997 cites W2064477837 @default.
• W2060819997 cites W2068804004 @default.
• W2060819997 cites W2069588559 @default.
• W2060819997 cites W2080737199 @default.
• W2060819997 cites W2081454679 @default.
• W2060819997 cites W2082909688 @default.
• W2060819997 cites W2098507180 @default.
• W2060819997 cites W2103144939 @default.
• W2060819997 cites W2106618245 @default.
• W2060819997 cites W2111053271 @default.
• W2060819997 cites W2116360606 @default.
• W2060819997 cites W2123737628 @default.
• W2060819997 cites W2127734104 @default.
• W2060819997 cites W2137682340 @default.
• W2060819997 cites W2140324175 @default.
• W2060819997 cites W2143362901 @default.
• W2060819997 cites W2144666092 @default.
• W2060819997 cites W2150969390 @default.
• W2060819997 cites W2154454234 @default.
• W2060819997 cites W2164859426 @default.
• W2060819997 cites W2430009818 @default.
• W2060819997 cites W4237666439 @default.
• W2060819997 doi "https://doi.org/10.1016/j.chembiol.2004.11.006" @default.
• W2060819997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15734646" @default.
• W2060819997 hasPublicationYear "2005" @default.
• W2060819997 type Work @default.
• W2060819997 sameAs 2060819997 @default.
• W2060819997 citedByCount "32" @default.
• W2060819997 countsByYear W20608199972012 @default.
• W2060819997 countsByYear W20608199972013 @default.
• W2060819997 countsByYear W20608199972014 @default.
• W2060819997 countsByYear W20608199972015 @default.
• W2060819997 countsByYear W20608199972016 @default.
• W2060819997 countsByYear W20608199972017 @default.
• W2060819997 countsByYear W20608199972019 @default.
• W2060819997 countsByYear W20608199972020 @default.
• W2060819997 countsByYear W20608199972021 @default.
• W2060819997 countsByYear W20608199972023 @default.
• W2060819997 crossrefType "journal-article" @default.
• W2060819997 hasAuthorship W2060819997A5009925574 @default.
• W2060819997 hasAuthorship W2060819997A5029616013 @default.
• W2060819997 hasAuthorship W2060819997A5048925702 @default.
• W2060819997 hasBestOaLocation W20608199971 @default.
• W2060819997 hasConcept C104317684 @default.
• W2060819997 hasConcept C112243037 @default.
• W2060819997 hasConcept C143065580 @default.
• W2060819997 hasConcept C165525559 @default.
• W2060819997 hasConcept C181199279 @default.
• W2060819997 hasConcept C185592680 @default.
• W2060819997 hasConcept C22744801 @default.
• W2060819997 hasConcept C2776060363 @default.
• W2060819997 hasConcept C2777573094 @default.
• W2060819997 hasConcept C2777915650 @default.
• W2060819997 hasConcept C2779920670 @default.
• W2060819997 hasConcept C2780681812 @default.
• W2060819997 hasConcept C2781374117 @default.
• W2060819997 hasConcept C515207424 @default.
• W2060819997 hasConcept C523546767 @default.
• W2060819997 hasConcept C54355233 @default.
• W2060819997 hasConcept C553450214 @default.
• W2060819997 hasConcept C55493867 @default.
• W2060819997 hasConcept C71240020 @default.
• W2060819997 hasConcept C86803240 @default.
• W2060819997 hasConceptScore W2060819997C104317684 @default.
• W2060819997 hasConceptScore W2060819997C112243037 @default.
• W2060819997 hasConceptScore W2060819997C143065580 @default.
• W2060819997 hasConceptScore W2060819997C165525559 @default.
• W2060819997 hasConceptScore W2060819997C181199279 @default.
• W2060819997 hasConceptScore W2060819997C185592680 @default.

• next