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- W2060833102 abstract "The aim of this study was to evaluate β-endorphin, ACTH, and cortisol plasma levels during metyrapone administration in man after chronic opioid receptor stimulation. Metyrapone (750 mg every 4hr for 6 doses) was administered to ten male heroin addicts, who had been on a maintenance therapy with methadone for at least 6 months and to ten healthy sex- and age-matched volunteers. Before metyrapone administration the basal levels of cortisol and ACTH were significantly decreased in addicts as compared to normal controls, while plasma β-endorphin was not different. The response of β-endorphin and ACTH to metyrapone administration was significantly blunted in addicts (p < 0.01). These results suggest that the chronic stimulation of opiate receptors can impair the function of the anterior pituitary gland." @default.
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- W2060833102 date "1990-03-01" @default.
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- W2060833102 title "Metyrapone effects on β-endorphin, ACTH and cortisol levels after chronic opiate receptor stimulation in man" @default.
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- W2060833102 doi "https://doi.org/10.1016/0143-4179(90)90143-m" @default.
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