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- W2060836163 abstract "Melittin interactions with lipid bilayers and melittin formed pores are extensively studied to understand the mechanism of the toroidal pore formation. Early experimental studies suggested that melittin peptide molecules are anchored by their positively charged residues located next to the C-terminus to only one leaflet of the lipid bilayer (asymmetric arrangement). However, the recent non-linear spectroscopic experiment suggests a symmetric arrangement of the peptides with the C-terminus of the peptides anchored to both bilayers. Therefore, we present here a computational study that compares the effect of symmetric and asymmetric arrangements of melittin peptides in the toroidal pore formation. We also investigate the role of the peptide secondary structure during the pore formation. Two sets of the symmetric and asymmetric pores are prepared, one with a helical peptide from the crystal structure and the other set with a less helical peptide. We observe a stable toroidal pore being formed only in the system with a symmetric arrangement of the less helical peptides. Based on the simulation results we propose that the symmetric arrangement of the peptides might be more favorable than the asymmetric arrangement, and that the helical secondary structure is not a prerequisite for the formation of the toroidal pore." @default.
- W2060836163 created "2016-06-24" @default.
- W2060836163 creator A5012707599 @default.
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- W2060836163 date "2011-09-01" @default.
- W2060836163 modified "2023-09-27" @default.
- W2060836163 title "Influence of the arrangement and secondary structure of melittin peptides on the formation and stability of toroidal pores" @default.
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- W2060836163 doi "https://doi.org/10.1016/j.bbamem.2011.04.021" @default.
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