Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060839103> ?p ?o ?g. }
- W2060839103 endingPage "3831" @default.
- W2060839103 startingPage "3823" @default.
- W2060839103 abstract "Caveolae, flask-like invaginations of the plasma membrane, were discovered nearly 60 years ago. Originally regarded as fixation artifacts of electron microscopy, the functional role for these structures has taken decades to unravel. The discovery of the caveolin protein in 1992 (by the late Richard G.W. Anderson) accelerated progress in defining the contribution of caveolae to cellular physiology and pathophysiology. The three isoforms of caveolin (caveolin-1, -2, and -3) are caveolae-resident structural and scaffolding proteins that are critical for the formation of caveolae and their localization of signaling entities. A PubMed search for “caveolae” reveals ~280 publications from their discovery in the 1950s to the early 1990s, whereas a search for “caveolae or caveolin” after 1990, identifies ~7000 entries. Most work on the regulation of biological responses by caveolae and caveolin since 1990 has focused on caveolae as plasma membrane microdomains and the function of caveolin proteins at the plasma membrane. By contrast, our recent work and that of others has explored the localization of caveolins in multiple cellular membrane compartments and in the regulation of intracellular signaling. Cellular organelles that contain caveolin include mitochondria, nuclei and the endoplasmic reticulum. Such intracellular localization allows for a complexity of responses to extracellular stimuli by caveolin and the possibility of novel organelle-targeted therapeutics. This review focuses on the impact of intracellular localization of caveolin on signal transduction and cell regulation.—Fridolfsson, H. N., Roth, D. M., Insel, P. A., Patel, H. H. Regulation of intracellular signaling and function by caveolin. FASEB J. 28, 3823-3831 (2014). www.fasebj.org" @default.
- W2060839103 created "2016-06-24" @default.
- W2060839103 creator A5014165479 @default.
- W2060839103 creator A5034957704 @default.
- W2060839103 creator A5048363770 @default.
- W2060839103 creator A5055677266 @default.
- W2060839103 date "2014-05-22" @default.
- W2060839103 modified "2023-10-12" @default.
- W2060839103 title "Regulation of intracellular signaling and function by caveolin" @default.
- W2060839103 cites W1493009573 @default.
- W2060839103 cites W1516421005 @default.
- W2060839103 cites W1518063279 @default.
- W2060839103 cites W1523839707 @default.
- W2060839103 cites W1527093201 @default.
- W2060839103 cites W1537548031 @default.
- W2060839103 cites W1546058994 @default.
- W2060839103 cites W1573886742 @default.
- W2060839103 cites W1606337626 @default.
- W2060839103 cites W1657488732 @default.
- W2060839103 cites W1685802105 @default.
- W2060839103 cites W1704145869 @default.
- W2060839103 cites W1869055623 @default.
- W2060839103 cites W19005219 @default.
- W2060839103 cites W1947733508 @default.
- W2060839103 cites W1965572772 @default.
- W2060839103 cites W1966629642 @default.
- W2060839103 cites W1974248631 @default.
- W2060839103 cites W1974624829 @default.
- W2060839103 cites W1974955986 @default.
- W2060839103 cites W1974993490 @default.
- W2060839103 cites W1976081253 @default.
- W2060839103 cites W1983034683 @default.
- W2060839103 cites W1985712533 @default.
- W2060839103 cites W1987732943 @default.
- W2060839103 cites W1989261260 @default.
- W2060839103 cites W1993803695 @default.
- W2060839103 cites W1996156489 @default.
- W2060839103 cites W1997044174 @default.
- W2060839103 cites W1997726565 @default.
- W2060839103 cites W1998103617 @default.
- W2060839103 cites W1998519909 @default.
- W2060839103 cites W1999385248 @default.
- W2060839103 cites W1999743098 @default.
- W2060839103 cites W1999748940 @default.
- W2060839103 cites W2002096723 @default.
- W2060839103 cites W2003414227 @default.
- W2060839103 cites W2004385261 @default.
- W2060839103 cites W2008159342 @default.
- W2060839103 cites W2008697541 @default.
- W2060839103 cites W2013788682 @default.
- W2060839103 cites W2015183893 @default.
- W2060839103 cites W2016923561 @default.
- W2060839103 cites W2019862207 @default.
- W2060839103 cites W2022561687 @default.
- W2060839103 cites W2023145731 @default.
- W2060839103 cites W2023468848 @default.
- W2060839103 cites W2028880044 @default.
- W2060839103 cites W2029603201 @default.
- W2060839103 cites W2035508242 @default.
- W2060839103 cites W2036145606 @default.
- W2060839103 cites W2036992381 @default.
- W2060839103 cites W2041298355 @default.
- W2060839103 cites W2041469335 @default.
- W2060839103 cites W2044154503 @default.
- W2060839103 cites W2044846711 @default.
- W2060839103 cites W2046053482 @default.
- W2060839103 cites W2053599433 @default.
- W2060839103 cites W2056125941 @default.
- W2060839103 cites W2062315382 @default.
- W2060839103 cites W2066812102 @default.
- W2060839103 cites W2074406830 @default.
- W2060839103 cites W2074753255 @default.
- W2060839103 cites W2075796682 @default.
- W2060839103 cites W2077711546 @default.
- W2060839103 cites W2082315075 @default.
- W2060839103 cites W2082775864 @default.
- W2060839103 cites W2084379296 @default.
- W2060839103 cites W2087394084 @default.
- W2060839103 cites W2092437783 @default.
- W2060839103 cites W2094872029 @default.
- W2060839103 cites W2096797584 @default.
- W2060839103 cites W2097111522 @default.
- W2060839103 cites W2099877712 @default.
- W2060839103 cites W2100602595 @default.
- W2060839103 cites W2104139918 @default.
- W2060839103 cites W2112465136 @default.
- W2060839103 cites W2115320622 @default.
- W2060839103 cites W2116803744 @default.
- W2060839103 cites W2117304280 @default.
- W2060839103 cites W2124317881 @default.
- W2060839103 cites W2125525614 @default.
- W2060839103 cites W2128923688 @default.
- W2060839103 cites W2128984918 @default.
- W2060839103 cites W2132675832 @default.
- W2060839103 cites W2140456056 @default.
- W2060839103 cites W2140482559 @default.
- W2060839103 cites W2140538678 @default.
- W2060839103 cites W2142613038 @default.