FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060839181> ?p ?o ?g. }

• W2060839181 endingPage "474" @default.
• W2060839181 startingPage "467" @default.
• W2060839181 abstract "Abstract Background Lipoprotein lipase (LPL) deficiency is a rare autosomal recessively inherited disease characterized by elevated triglyceride, low total cholesterol and quantitative and qualitative alterations of high‐density lipoprotein (HDL). The aim of the present study was to explore HDL metabolic activities in a patient with LPL deficiency and in his family ( n = 11). Materials and methods Subjects were divided into four groups: proband (Ser447Stop/Arg170Leu carrier), Ser447Stop carriers, Arg170Leu carriers and silent mutation/wild‐type carriers (controls). Cholesterol efflux from Fu5AH cells, lecithin:cholesterol acyltransferase (LCAT), cholesteryl ester transfer protein (CETP), paraoxonase 1 (PON1) and platelet‐activating factor acetylhydrolase (PAF‐AH) activities were evaluated. Results Comparison between the proband and the control group revealed that the boy had significantly reduced cholesterol efflux ( P < 0·001), conserved LCAT activity ( P > 0·05) and increased CETP activity ( P < 0·001). As regards antioxidant enzymes, while PON1 activity was higher in the proband than in the controls ( P < 0·0001), PAF‐AH activity was reduced ( P < 0·05). The other groups did not show relevant differences in comparison with controls. Conclusions The presence of one mutation was not enough to introduce important modifications in HDL functions. Markedly reduced HDL levels can keep certain normal enzymatic activities, which probably tend to counteract the deleterious effects of LPL deficiency." @default.
• W2060839181 created "2016-06-24" @default.
• W2060839181 creator A5010832465 @default.
• W2060839181 creator A5035876498 @default.
• W2060839181 creator A5046838147 @default.
• W2060839181 creator A5047980767 @default.
• W2060839181 creator A5057699783 @default.
• W2060839181 creator A5058385134 @default.
• W2060839181 creator A5060728312 @default.
• W2060839181 creator A5068057183 @default.
• W2060839181 date "2004-07-01" @default.
• W2060839181 modified "2023-10-15" @default.
• W2060839181 title "HDL metabolic activities in a boy with lipoprotein lipase deficiency and his family" @default.
• W2060839181 cites W1513897103 @default.
• W2060839181 cites W1583078163 @default.
• W2060839181 cites W1857052429 @default.
• W2060839181 cites W1860487341 @default.
• W2060839181 cites W1909574472 @default.
• W2060839181 cites W1947043095 @default.
• W2060839181 cites W1966640590 @default.
• W2060839181 cites W1980434488 @default.
• W2060839181 cites W1985794857 @default.
• W2060839181 cites W1993613154 @default.
• W2060839181 cites W2004881914 @default.
• W2060839181 cites W2015987701 @default.
• W2060839181 cites W2036383576 @default.
• W2060839181 cites W2049698305 @default.
• W2060839181 cites W2061315559 @default.
• W2060839181 cites W2065784134 @default.
• W2060839181 cites W2083392018 @default.
• W2060839181 cites W2088365138 @default.
• W2060839181 cites W2093225381 @default.
• W2060839181 cites W2095885613 @default.
• W2060839181 cites W2099148881 @default.
• W2060839181 cites W2104399391 @default.
• W2060839181 cites W2105405913 @default.
• W2060839181 cites W2112112197 @default.
• W2060839181 cites W2113504642 @default.
• W2060839181 cites W2121788140 @default.
• W2060839181 cites W2129788418 @default.
• W2060839181 cites W2140925625 @default.
• W2060839181 cites W2149382475 @default.
• W2060839181 cites W2150545098 @default.
• W2060839181 cites W2161071771 @default.
• W2060839181 cites W2167419085 @default.
• W2060839181 cites W2169253083 @default.
• W2060839181 cites W2189552099 @default.
• W2060839181 cites W2337989971 @default.
• W2060839181 cites W2398093727 @default.
• W2060839181 cites W2999618659 @default.
• W2060839181 doi "https://doi.org/10.1111/j.1365-2362.2004.01360.x" @default.
• W2060839181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15255783" @default.
• W2060839181 hasPublicationYear "2004" @default.
• W2060839181 type Work @default.
• W2060839181 sameAs 2060839181 @default.
• W2060839181 citedByCount "4" @default.
• W2060839181 countsByYear W20608391812020 @default.
• W2060839181 countsByYear W20608391812022 @default.
• W2060839181 crossrefType "journal-article" @default.
• W2060839181 hasAuthorship W2060839181A5010832465 @default.
• W2060839181 hasAuthorship W2060839181A5035876498 @default.
• W2060839181 hasAuthorship W2060839181A5046838147 @default.
• W2060839181 hasAuthorship W2060839181A5047980767 @default.
• W2060839181 hasAuthorship W2060839181A5057699783 @default.
• W2060839181 hasAuthorship W2060839181A5058385134 @default.
• W2060839181 hasAuthorship W2060839181A5060728312 @default.
• W2060839181 hasAuthorship W2060839181A5068057183 @default.
• W2060839181 hasConcept C104317684 @default.
• W2060839181 hasConcept C110459506 @default.
• W2060839181 hasConcept C126322002 @default.
• W2060839181 hasConcept C134018914 @default.
• W2060839181 hasConcept C135763542 @default.
• W2060839181 hasConcept C181199279 @default.
• W2060839181 hasConcept C185592680 @default.
• W2060839181 hasConcept C188997412 @default.
• W2060839181 hasConcept C2776151105 @default.
• W2060839181 hasConcept C2776509667 @default.
• W2060839181 hasConcept C2778163477 @default.
• W2060839181 hasConcept C2778913445 @default.
• W2060839181 hasConcept C2779564620 @default.
• W2060839181 hasConcept C2779697368 @default.
• W2060839181 hasConcept C2780072125 @default.
• W2060839181 hasConcept C2780213950 @default.
• W2060839181 hasConcept C2780541478 @default.
• W2060839181 hasConcept C37002583 @default.
• W2060839181 hasConcept C37501387 @default.
• W2060839181 hasConcept C45505151 @default.
• W2060839181 hasConcept C501734568 @default.
• W2060839181 hasConcept C55493867 @default.
• W2060839181 hasConcept C71924100 @default.
• W2060839181 hasConcept C86803240 @default.
• W2060839181 hasConcept C94879076 @default.
• W2060839181 hasConceptScore W2060839181C104317684 @default.
• W2060839181 hasConceptScore W2060839181C110459506 @default.
• W2060839181 hasConceptScore W2060839181C126322002 @default.
• W2060839181 hasConceptScore W2060839181C134018914 @default.
• W2060839181 hasConceptScore W2060839181C135763542 @default.
• W2060839181 hasConceptScore W2060839181C181199279 @default.

• next