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• W2060842170 abstract "A comparison has been made between several different compartmental and non-compartmental methods for analyzing human calcium kinetics. Using data from studies in six normal subjects, plus a computer-generated set of “error-free” data, the bone accretion rate and the exchangeable calcium pool size have been calculated by each method, along with their corresponding uncertainties. The effects of selective deletions of data have also been determined for the various methods. The results are highly dependent upon the model employed and the parameter investigated. In general, the non-compartmental models provide accretion rates which are less sensitive to measurement errors, and have less stringent requirements as to the necessary duration of an experimental study. Among compartmental models, a three-compartment model based on data collected from two hours to twenty days after isotopic calcium injection gives estimates of skeletal accretion rate and exchangeable pool size very similar to those resulting from a four-compartment model that includes additional earlier data. The relative advantages of various compartmental and non-compartmental methods of analysis are discussed in relation to these results, and practical recommendations offered to the clinical investigator." @default.
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• W2060842170 date "1978-07-01" @default.
• W2060842170 modified "2023-09-23" @default.
• W2060842170 title "Critical analysis of methods for analysing human calcium kinetics" @default.
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• W2060842170 doi "https://doi.org/10.1016/0022-5193(78)90183-2" @default.
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