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- W2060845147 abstract "<h2>Abstract</h2> The effect of <i>N,N</i>-dimethyl-, <i>N,N</i>-diethyl-, <i>N,N</i>-di-<i>n</i>-propyl-, and <i>N,N</i>-di-<i>n</i>-butylpropionamide on the absorption of prednisone and prednisolone in aqueous solution from the rat small intestine was studied. The propyl and butyl compounds (initial concentration 28 m<i>M</i>) enhanced significantly the absorption of both steroids (initial concentration 0.5 m<i>M</i>). The ethyl compound had a less pronounced effect, while the methyl derivative did not significantly affect the absorption of the two steroids. The absorption-enhancing effect of the amides is concentration dependent and is rapidly and completely reversible. It appears to be due to the formation of a steroid-amide complex within the intestinal barrier." @default.
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- W2060845147 date "1972-03-01" @default.
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- W2060845147 title "Effect of Complex Formation on Drug Absorption XII: Enhancement of Intestinal Absorption of Prednisone and Prednisolone by Dialkylpropionamides in Rats" @default.
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- W2060845147 doi "https://doi.org/10.1002/jps.2600610308" @default.
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