Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060851302> ?p ?o ?g. }
- W2060851302 endingPage "1114" @default.
- W2060851302 startingPage "1107" @default.
- W2060851302 abstract "Lanthanides, also called rare-earth elements, are an interesting group of 15 chemically active, mainly trivalent, f-electronic, silvery-white metals. In fact, lanthanides are not as rare as the name implies, except for promethium, a radioactive artificial element not found in nature. The mean concentrations of lanthanides in the earth's crust are comparable to those of life-important elements like iodine, cobalt and selenium. Many lanthanide compounds show particular magnetic, catalytic and optic properties, and that is why their technical applications are so extensive. Numerous industrial sources enable lanthanides to penetrate into the human body and therefore detailed toxicological studies of these metals are necessary. In the liver, gadolinium selectively inhibits secretion by Kupffer cells and it decreases cytochrome P450 activity in hepatocytes, thereby protecting liver cells against toxic products of xenobiotic biotransformation. Praseodymium ion (Pr3+) produces the same protective effect in liver tissue cultures. Cytophysiological effects of lanthanides appear to result from the similarity of their cationic radii to the size of Ca2+ ions. Trivalent lanthanide ions, especially La3+ and Gd3+, block different calcium channels in human and animal cells. Lanthanides can affect numerous enzymes: Dy3+ and La3+ block Ca2+-ATPase and Mg2+-ATPase, while Eu3+ and Tb3+ inhibit calcineurin. In neurons, lanthanide ions regulate the transport and release of synaptic transmitters and block some membrane receptors, e.g. GABA and glutamate receptors. It is likely that lanthanides significantly and uniquely affect biochemical pathways, thus altering physiological processes in the tissues of humans and animals." @default.
- W2060851302 created "2016-06-24" @default.
- W2060851302 creator A5006211966 @default.
- W2060851302 creator A5085495427 @default.
- W2060851302 date "2000-12-31" @default.
- W2060851302 modified "2023-10-14" @default.
- W2060851302 title "Toxicological and cytophysiological aspects of lanthanides action." @default.
- W2060851302 cites W103744737 @default.
- W2060851302 cites W1676198809 @default.
- W2060851302 cites W1814468920 @default.
- W2060851302 cites W1969509136 @default.
- W2060851302 cites W1974288850 @default.
- W2060851302 cites W1983181965 @default.
- W2060851302 cites W1983471001 @default.
- W2060851302 cites W1986092783 @default.
- W2060851302 cites W1987444800 @default.
- W2060851302 cites W1998900327 @default.
- W2060851302 cites W2012577614 @default.
- W2060851302 cites W2025285818 @default.
- W2060851302 cites W2027340801 @default.
- W2060851302 cites W2027461539 @default.
- W2060851302 cites W2028559375 @default.
- W2060851302 cites W2033635345 @default.
- W2060851302 cites W2035530290 @default.
- W2060851302 cites W2049028831 @default.
- W2060851302 cites W2049392486 @default.
- W2060851302 cites W2050180520 @default.
- W2060851302 cites W2058722943 @default.
- W2060851302 cites W2059087206 @default.
- W2060851302 cites W2064018921 @default.
- W2060851302 cites W2064020505 @default.
- W2060851302 cites W2064987965 @default.
- W2060851302 cites W2065111707 @default.
- W2060851302 cites W2065547702 @default.
- W2060851302 cites W2068617048 @default.
- W2060851302 cites W2072884571 @default.
- W2060851302 cites W2106534757 @default.
- W2060851302 cites W2112020251 @default.
- W2060851302 cites W2113333095 @default.
- W2060851302 cites W2158347788 @default.
- W2060851302 cites W2265617514 @default.
- W2060851302 cites W2527756305 @default.
- W2060851302 doi "https://doi.org/10.18388/abp.2000_3963" @default.
- W2060851302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11996100" @default.
- W2060851302 hasPublicationYear "2000" @default.
- W2060851302 type Work @default.
- W2060851302 sameAs 2060851302 @default.
- W2060851302 citedByCount "208" @default.
- W2060851302 countsByYear W20608513022012 @default.
- W2060851302 countsByYear W20608513022013 @default.
- W2060851302 countsByYear W20608513022014 @default.
- W2060851302 countsByYear W20608513022015 @default.
- W2060851302 countsByYear W20608513022016 @default.
- W2060851302 countsByYear W20608513022017 @default.
- W2060851302 countsByYear W20608513022018 @default.
- W2060851302 countsByYear W20608513022019 @default.
- W2060851302 countsByYear W20608513022020 @default.
- W2060851302 countsByYear W20608513022021 @default.
- W2060851302 countsByYear W20608513022022 @default.
- W2060851302 countsByYear W20608513022023 @default.
- W2060851302 crossrefType "journal-article" @default.
- W2060851302 hasAuthorship W2060851302A5006211966 @default.
- W2060851302 hasAuthorship W2060851302A5085495427 @default.
- W2060851302 hasBestOaLocation W20608513021 @default.
- W2060851302 hasConcept C12554922 @default.
- W2060851302 hasConcept C145148216 @default.
- W2060851302 hasConcept C178790620 @default.
- W2060851302 hasConcept C179104552 @default.
- W2060851302 hasConcept C185592680 @default.
- W2060851302 hasConcept C201770740 @default.
- W2060851302 hasConcept C537997061 @default.
- W2060851302 hasConcept C55493867 @default.
- W2060851302 hasConcept C86803240 @default.
- W2060851302 hasConceptScore W2060851302C12554922 @default.
- W2060851302 hasConceptScore W2060851302C145148216 @default.
- W2060851302 hasConceptScore W2060851302C178790620 @default.
- W2060851302 hasConceptScore W2060851302C179104552 @default.
- W2060851302 hasConceptScore W2060851302C185592680 @default.
- W2060851302 hasConceptScore W2060851302C201770740 @default.
- W2060851302 hasConceptScore W2060851302C537997061 @default.
- W2060851302 hasConceptScore W2060851302C55493867 @default.
- W2060851302 hasConceptScore W2060851302C86803240 @default.
- W2060851302 hasIssue "4" @default.
- W2060851302 hasLocation W20608513021 @default.
- W2060851302 hasLocation W20608513022 @default.
- W2060851302 hasOpenAccess W2060851302 @default.
- W2060851302 hasPrimaryLocation W20608513021 @default.
- W2060851302 hasRelatedWork W2015342683 @default.
- W2060851302 hasRelatedWork W2036561936 @default.
- W2060851302 hasRelatedWork W2040442972 @default.
- W2060851302 hasRelatedWork W2068093162 @default.
- W2060851302 hasRelatedWork W2323781205 @default.
- W2060851302 hasRelatedWork W2345403763 @default.
- W2060851302 hasRelatedWork W2399889525 @default.
- W2060851302 hasRelatedWork W2572617773 @default.
- W2060851302 hasRelatedWork W2951378103 @default.
- W2060851302 hasRelatedWork W2518552235 @default.
- W2060851302 hasVolume "47" @default.