Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060855061> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2060855061 endingPage "645" @default.
- W2060855061 startingPage "640" @default.
- W2060855061 abstract "In influencing risk for psychiatric and substance use disorders, genes are typically conceptualized as working in silent physiological pathways in the bowels of our biology, far from the influences of human desires. I here argue that this model of gene action is too restricted. At the individual, family and societal level, humans can, through their decision-making capacity, intervene in causal pathways from genes to behavior. At the individual level, I present four paradigmatic cases involving alcohol dependence, major depression, general externalizing behaviors and animal phobia showing how human decisions can inhibit the expression of risk genes. I review the literatures demonstrating that parental behaviors can suppress or augment the heritability of traits in their children, and social attitudes can alter and even create causal pathways from genes to phenotypes. We evolved from organisms whose nervous systems were networks of reflexes that then developed simple cognitive systems and finally self-reflection. Just as our cognitions have gone ‘meta,’ we are now nearing a time when we can go ‘meta’ about our genetic risk. For many psychiatric disorders, our risk genes are not entirely cordoned off in our silent, purposeless biological substrate. Rather, we are able to make decisions that impact on the expression of our own genomes, those of our loved ones and those of our friends and neighbors. Our actions and our genes are often weaved together, integrated into the fabric of our lives." @default.
- W2060855061 created "2016-06-24" @default.
- W2060855061 creator A5011961838 @default.
- W2060855061 date "2012-11-06" @default.
- W2060855061 modified "2023-10-15" @default.
- W2060855061 title "Decision making in the pathway from genes to psychiatric and substance use disorders" @default.
- W2060855061 cites W1589737427 @default.
- W2060855061 cites W1964631257 @default.
- W2060855061 cites W1968156182 @default.
- W2060855061 cites W1969407305 @default.
- W2060855061 cites W1970760620 @default.
- W2060855061 cites W1988657055 @default.
- W2060855061 cites W1989113721 @default.
- W2060855061 cites W1991475702 @default.
- W2060855061 cites W2000880797 @default.
- W2060855061 cites W2003189192 @default.
- W2060855061 cites W2005245306 @default.
- W2060855061 cites W2005821863 @default.
- W2060855061 cites W2019073365 @default.
- W2060855061 cites W2061423463 @default.
- W2060855061 cites W2068415928 @default.
- W2060855061 cites W2074116934 @default.
- W2060855061 cites W2076401526 @default.
- W2060855061 cites W2087025655 @default.
- W2060855061 cites W2088165831 @default.
- W2060855061 cites W2093248423 @default.
- W2060855061 cites W2106294125 @default.
- W2060855061 cites W2125950905 @default.
- W2060855061 cites W2127884280 @default.
- W2060855061 cites W2132074574 @default.
- W2060855061 cites W2132449499 @default.
- W2060855061 cites W2135382793 @default.
- W2060855061 cites W2145194866 @default.
- W2060855061 cites W2148304141 @default.
- W2060855061 cites W2151055409 @default.
- W2060855061 cites W2151806195 @default.
- W2060855061 cites W2157383890 @default.
- W2060855061 cites W2163898634 @default.
- W2060855061 cites W4206711605 @default.
- W2060855061 cites W4255807842 @default.
- W2060855061 cites W625960733 @default.
- W2060855061 doi "https://doi.org/10.1038/mp.2012.151" @default.
- W2060855061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3663891" @default.
- W2060855061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23128152" @default.
- W2060855061 hasPublicationYear "2012" @default.
- W2060855061 type Work @default.
- W2060855061 sameAs 2060855061 @default.
- W2060855061 citedByCount "18" @default.
- W2060855061 countsByYear W20608550612013 @default.
- W2060855061 countsByYear W20608550612014 @default.
- W2060855061 countsByYear W20608550612015 @default.
- W2060855061 countsByYear W20608550612016 @default.
- W2060855061 countsByYear W20608550612017 @default.
- W2060855061 countsByYear W20608550612018 @default.
- W2060855061 countsByYear W20608550612019 @default.
- W2060855061 countsByYear W20608550612020 @default.
- W2060855061 countsByYear W20608550612021 @default.
- W2060855061 crossrefType "journal-article" @default.
- W2060855061 hasAuthorship W2060855061A5011961838 @default.
- W2060855061 hasBestOaLocation W20608550611 @default.
- W2060855061 hasConcept C118552586 @default.
- W2060855061 hasConcept C138496976 @default.
- W2060855061 hasConcept C15744967 @default.
- W2060855061 hasConcept C169900460 @default.
- W2060855061 hasConcept C70410870 @default.
- W2060855061 hasConceptScore W2060855061C118552586 @default.
- W2060855061 hasConceptScore W2060855061C138496976 @default.
- W2060855061 hasConceptScore W2060855061C15744967 @default.
- W2060855061 hasConceptScore W2060855061C169900460 @default.
- W2060855061 hasConceptScore W2060855061C70410870 @default.
- W2060855061 hasIssue "6" @default.
- W2060855061 hasLocation W20608550611 @default.
- W2060855061 hasLocation W20608550612 @default.
- W2060855061 hasLocation W20608550613 @default.
- W2060855061 hasLocation W20608550614 @default.
- W2060855061 hasOpenAccess W2060855061 @default.
- W2060855061 hasPrimaryLocation W20608550611 @default.
- W2060855061 hasRelatedWork W1968116410 @default.
- W2060855061 hasRelatedWork W1981682337 @default.
- W2060855061 hasRelatedWork W2016713905 @default.
- W2060855061 hasRelatedWork W2030000401 @default.
- W2060855061 hasRelatedWork W2052460212 @default.
- W2060855061 hasRelatedWork W2064484569 @default.
- W2060855061 hasRelatedWork W2092756134 @default.
- W2060855061 hasRelatedWork W2150658094 @default.
- W2060855061 hasRelatedWork W2334446790 @default.
- W2060855061 hasRelatedWork W4241181729 @default.
- W2060855061 hasVolume "18" @default.
- W2060855061 isParatext "false" @default.
- W2060855061 isRetracted "false" @default.
- W2060855061 magId "2060855061" @default.
- W2060855061 workType "article" @default.