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• W2060877430 abstract "• Fifteen compounds were isolated from Garcinia hombroniana . • Compounds 1 and 9 induced DBTRG cells death. • Compounds 1 – 8 exhibited strong antioxidant activities. Garcinia hombroniana (seashore mangosteen) in Malaysia is used to treat itching and as a protective medicine after child birth. This study was aimed to investigate the bioactive chemical constituents of the bark of G. hombroniana . Ethyl acetate and dichloromethane extracts of G. hombroniana yielded two new ( 1 , 9 ) and thirteen known compounds which were characterized by the spectral techniques of NMR, UV, IR and EI/ESI-MS, and identified as; 2,3′,4,5′-tetrahydroxy-6-methoxybenzophenone ( 1 ), 2,3′,4,4′-tetrahydroxy-6-methoxybenzophenone ( 2 ), 2,3′,4,6-tetrahydroxybenzophenone ( 3 ), 1,3,6,7-tetrahydroxyxanthone ( 4 ), 3,3′,4′,5,7-pentahydroxyflavone ( 5 ), 3,3′,5,5′,7-pentahydroxyflavanone ( 6 ), 3,3′,4′,5,5′,7-hexahydroxyflavone ( 7 ), 4′,5,7-trihydroxyflavanone-7-rutinoside ( 8 ), 18(13 → 17)-abeo-3 β -acetoxy-9 α ,13 β -lanost-24 E -en-26-oic acid ( 9 ), garcihombronane B ( 10 ), garcihombronane D ( 11 ), friedelan-3-one ( 12 ), lupeol ( 13 ), stigmasterol ( 14 ) and stigmasterol glucoside ( 15 ). In the in vitro cytotoxicity against MCF-7, DBTRG, U2OS and PC-3 cell lines, compounds 1 and 9 displayed good cytotoxic effects against DBTRG cancer cell lines. Compounds 1 – 8 were also found to possess significant antioxidant activities. Owing to these properties, this study can be further extended to explore more significant bioactive components of this plant." @default.
• W2060877430 created "2016-06-24" @default.
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• W2060877430 date "2014-06-01" @default.
• W2060877430 modified "2023-10-18" @default.
• W2060877430 title "Cytotoxic benzophenone and triterpene from Garcinia hombroniana" @default.
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• W2060877430 doi "https://doi.org/10.1016/j.bioorg.2014.04.003" @default.
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