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- W2060879241 abstract "Abstract The synthesis of eight 16α-propyl derivatives of estradiol is described, and structure-activity relationships are discussed. Potent inhibitors of cytosolic 17β-hydroxysteroid dehydrogenase of human placenta (type 1) can be obtained when a good leaving group is located at the end of a 16α-propyl side chain; the 16α-(iodopropyl)-estradiol (7) and 16α-(bromopropyl)-estradiol (6) gave the best irreversible inhibitions of 17β-HSD type 1, with IC50 values of 0.42 and 0.46 μM, respectively." @default.
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- W2060879241 date "1994-09-01" @default.
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- W2060879241 title "16α-propyl derivatives of estradiol as inhibitors of 17β-hydroxysteroid dehydrogenase type 1" @default.
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- W2060879241 doi "https://doi.org/10.1016/s0960-894x(01)80115-3" @default.
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