FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060880334> ?p ?o ?g. }

• W2060880334 endingPage "104" @default.
• W2060880334 startingPage "96" @default.
• W2060880334 abstract "The asparagine-X-serine/threonine (NXS/T) motif, where X is any amino acid except proline, is the consensus motif for N-linked glycosylation. Significant numbers of high-resolution crystal structures of glycosylated proteins allow us to carry out structural analysis of the N-linked glycosylation sites (NGS). Our analysis shows that there is enough structural information from diverse glycoproteins to allow the development of rules which can be used to predict NGS. A Python-based tool was developed to investigate asparagines implicated in N-glycosylation in five species: Homo sapiens, Mus musculus, Drosophila melanogaster, Arabidopsis thaliana and Saccharomyces cerevisiae. Our analysis shows that 78% of all asparagines of NXS/T motif involved in N-glycosylation are localized in the loop/turn conformation in the human proteome. Similar distribution was revealed for all the other species examined. Comparative analysis of the occurrence of NXS/T motifs not known to be glycosylated and their reverse sequence (S/TXN) shows a similar distribution across the secondary structural elements, indicating that the NXS/T motif in itself is not biologically relevant. Based on our analysis, we have defined rules to determine NGS. Using machine learning methods based on these rules we can predict with 93% accuracy if a particular site will be glycosylated. If structural information is not available the tool uses structural prediction results resulting in 74% accuracy. The tool was used to identify glycosylation sites in 108 human proteins with structures and 2247 proteins without structures that have acquired NXS/T site/s due to non-synonymous variation. The tool, Structure Feature Analysis Tool (SFAT), is freely available to the public at http://hive.biochemistry.gwu.edu/tools/sfat." @default.
• W2060880334 created "2016-06-24" @default.
• W2060880334 creator A5014028889 @default.
• W2060880334 creator A5020517234 @default.
• W2060880334 creator A5026379467 @default.
• W2060880334 creator A5035615708 @default.
• W2060880334 creator A5054075163 @default.
• W2060880334 creator A5059419359 @default.
• W2060880334 creator A5081929979 @default.
• W2060880334 date "2013-04-01" @default.
• W2060880334 modified "2023-10-05" @default.
• W2060880334 title "Structure-based Comparative Analysis and Prediction of N-linked Glycosylation Sites in Evolutionarily Distant Eukaryotes" @default.
• W2060880334 cites W1519266993 @default.
• W2060880334 cites W1803394363 @default.
• W2060880334 cites W1947454816 @default.
• W2060880334 cites W1979803040 @default.
• W2060880334 cites W1981658018 @default.
• W2060880334 cites W2005750609 @default.
• W2060880334 cites W2011732398 @default.
• W2060880334 cites W2015064119 @default.
• W2060880334 cites W2024191848 @default.
• W2060880334 cites W2034281973 @default.
• W2060880334 cites W2035784347 @default.
• W2060880334 cites W2038335468 @default.
• W2060880334 cites W2045868744 @default.
• W2060880334 cites W2050525925 @default.
• W2060880334 cites W2053322857 @default.
• W2060880334 cites W2063768466 @default.
• W2060880334 cites W2076709027 @default.
• W2060880334 cites W2076746539 @default.
• W2060880334 cites W2077391745 @default.
• W2060880334 cites W2083014488 @default.
• W2060880334 cites W2099886875 @default.
• W2060880334 cites W2104836191 @default.
• W2060880334 cites W2108366237 @default.
• W2060880334 cites W2122732537 @default.
• W2060880334 cites W2125353047 @default.
• W2060880334 cites W2126103104 @default.
• W2060880334 cites W2129232972 @default.
• W2060880334 cites W2143404508 @default.
• W2060880334 cites W2149369491 @default.
• W2060880334 cites W2170441710 @default.
• W2060880334 cites W4231041617 @default.
• W2060880334 cites W4233334497 @default.
• W2060880334 cites W4250681326 @default.
• W2060880334 cites W74841586 @default.
• W2060880334 doi "https://doi.org/10.1016/j.gpb.2012.11.003" @default.
• W2060880334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3914773" @default.
• W2060880334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23459159" @default.
• W2060880334 hasPublicationYear "2013" @default.
• W2060880334 type Work @default.
• W2060880334 sameAs 2060880334 @default.
• W2060880334 citedByCount "47" @default.
• W2060880334 countsByYear W20608803342014 @default.
• W2060880334 countsByYear W20608803342015 @default.
• W2060880334 countsByYear W20608803342016 @default.
• W2060880334 countsByYear W20608803342017 @default.
• W2060880334 countsByYear W20608803342018 @default.
• W2060880334 countsByYear W20608803342019 @default.
• W2060880334 countsByYear W20608803342020 @default.
• W2060880334 countsByYear W20608803342021 @default.
• W2060880334 countsByYear W20608803342022 @default.
• W2060880334 countsByYear W20608803342023 @default.
• W2060880334 crossrefType "journal-article" @default.
• W2060880334 hasAuthorship W2060880334A5014028889 @default.
• W2060880334 hasAuthorship W2060880334A5020517234 @default.
• W2060880334 hasAuthorship W2060880334A5026379467 @default.
• W2060880334 hasAuthorship W2060880334A5035615708 @default.
• W2060880334 hasAuthorship W2060880334A5054075163 @default.
• W2060880334 hasAuthorship W2060880334A5059419359 @default.
• W2060880334 hasAuthorship W2060880334A5081929979 @default.
• W2060880334 hasBestOaLocation W20608803341 @default.
• W2060880334 hasConcept C11960822 @default.
• W2060880334 hasConcept C132677234 @default.
• W2060880334 hasConcept C144024400 @default.
• W2060880334 hasConcept C19165224 @default.
• W2060880334 hasConcept C2775880066 @default.
• W2060880334 hasConcept C2775895851 @default.
• W2060880334 hasConcept C2776414213 @default.
• W2060880334 hasConcept C2777313579 @default.
• W2060880334 hasConcept C2777938546 @default.
• W2060880334 hasConcept C515207424 @default.
• W2060880334 hasConcept C54355233 @default.
• W2060880334 hasConcept C55493867 @default.
• W2060880334 hasConcept C70721500 @default.
• W2060880334 hasConcept C86803240 @default.
• W2060880334 hasConceptScore W2060880334C11960822 @default.
• W2060880334 hasConceptScore W2060880334C132677234 @default.
• W2060880334 hasConceptScore W2060880334C144024400 @default.
• W2060880334 hasConceptScore W2060880334C19165224 @default.
• W2060880334 hasConceptScore W2060880334C2775880066 @default.
• W2060880334 hasConceptScore W2060880334C2775895851 @default.
• W2060880334 hasConceptScore W2060880334C2776414213 @default.
• W2060880334 hasConceptScore W2060880334C2777313579 @default.
• W2060880334 hasConceptScore W2060880334C2777938546 @default.
• W2060880334 hasConceptScore W2060880334C515207424 @default.
• W2060880334 hasConceptScore W2060880334C54355233 @default.
• W2060880334 hasConceptScore W2060880334C55493867 @default.

• next