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• W2060888966 abstract "Although it is clear that B cell genesis declines with age, the specifics of why this happens are largely unknown. Even less clear is how the age-related decline in B cell development might affect peripheral B cell function. Recent studies have investigated the impact of aging on both B cell genesis in the bone marrow and the resulting peripheral B cell repertoire. On the basis of these studies we propose a model in which the aging of very early B cell progenitors results in shifts in the peripheral B cell repertoire and, consequently, changes in mature B cell function." @default.
• W2060888966 created "2016-06-24" @default.
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• W2060888966 date "2005-10-01" @default.
• W2060888966 modified "2023-10-14" @default.
• W2060888966 title "B cell development and receptor diversity during aging" @default.
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• W2060888966 doi "https://doi.org/10.1016/j.coi.2005.07.002" @default.
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