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- W2060896000 abstract "The cellular composition and Vn-gene family repertoire were compared in different B-cell compartments from young adult (8–12 weeks) and old (18–24 months) C57BL/6 and BALB/c mice. Ageing mice were found to have a higher frequency of peripheral mature B cells utilizing genes from a single VH-gene family. While in each individual old C57BL/6 mice cells expressing the VH J558 gene family consistently were over-represented, a marked individual variation was observed in old BALB/c mice with increased frequency of either the Vh J558, Q52 or J606 families. Aged mice were found also to have a reduced number of bone-marrow pre-B cells and an augmented number of splenic Ig-secreting cells. These results suggest that old mice express less diversified antibody repertoires possibly as a consequence of reduced input from precursors and increased peripheral selection, which may be responsible for the progressive establishment of immunodeficiency." @default.
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- W2060896000 date "1994-02-01" @default.
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- W2060896000 title "VH-Gene Family Dominance in Ageing Mice" @default.
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- W2060896000 doi "https://doi.org/10.1111/j.1365-3083.1994.tb03358.x" @default.
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