Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060902613> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2060902613 abstract "The possible role of fluroacetate in the toxicity and antitumour activity of the fluroethylnitrosoureas, BFNU and FCNU has been studied in CBA mice bearing the TLX5 lymphoma either sensitive (TLXS) or resistant (TLXRT) to nitrosoureas. Treatment of mice bearing either TLXS or TLXRT tumours with either BFNU or FCNU caused an elevation in the citrate levels of heart, kidney and tumour, but not the liver, 24 hr after drug administration. Heart citrate levels were maximally elevated 10-fold, while the levels in kidney and tumour were increased 3- to 6-fold. Tissue levels of flurocitrate were determined by glc after conversion to the ethyl ester. This showed maximum levels of fluroacetate production in heart, with lower levels in kidney, tumour and liver. Treatment of K562 human erythroleukaemia cells in vitro with BFNU caused an inhibition in the production of 14CO2 from 14C palmitate and [U-14C] glucose. These results suggest that some of the effects of the fluroethylnitrosoureas may be related to fluroacetate production and the consequent blocking effect on aconitase. This effect is probably related more to the generalized toxicity of these agents than to their therapeutic efficacy." @default.
- W2060902613 created "2016-06-24" @default.
- W2060902613 creator A5010015013 @default.
- W2060902613 creator A5038017541 @default.
- W2060902613 date "1985-09-01" @default.
- W2060902613 modified "2023-10-18" @default.
- W2060902613 title "Role of fluroacetate in the toxicity of 2-fluroethylnitrosoureas" @default.
- W2060902613 cites W132744343 @default.
- W2060902613 cites W1981738200 @default.
- W2060902613 cites W1984267527 @default.
- W2060902613 cites W2013903319 @default.
- W2060902613 cites W2018346965 @default.
- W2060902613 cites W2034171083 @default.
- W2060902613 cites W2038121077 @default.
- W2060902613 cites W2080083125 @default.
- W2060902613 cites W2211500116 @default.
- W2060902613 cites W2410974591 @default.
- W2060902613 cites W30501010 @default.
- W2060902613 doi "https://doi.org/10.1016/0006-2952(85)90353-3" @default.
- W2060902613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4038340" @default.
- W2060902613 hasPublicationYear "1985" @default.
- W2060902613 type Work @default.
- W2060902613 sameAs 2060902613 @default.
- W2060902613 citedByCount "7" @default.
- W2060902613 countsByYear W20609026132015 @default.
- W2060902613 countsByYear W20609026132020 @default.
- W2060902613 crossrefType "journal-article" @default.
- W2060902613 hasAuthorship W2060902613A5010015013 @default.
- W2060902613 hasAuthorship W2060902613A5038017541 @default.
- W2060902613 hasConcept C126322002 @default.
- W2060902613 hasConcept C134018914 @default.
- W2060902613 hasConcept C150903083 @default.
- W2060902613 hasConcept C181199279 @default.
- W2060902613 hasConcept C185592680 @default.
- W2060902613 hasConcept C19831878 @default.
- W2060902613 hasConcept C200886947 @default.
- W2060902613 hasConcept C202751555 @default.
- W2060902613 hasConcept C207001950 @default.
- W2060902613 hasConcept C2780035454 @default.
- W2060902613 hasConcept C2780091579 @default.
- W2060902613 hasConcept C29730261 @default.
- W2060902613 hasConcept C55493867 @default.
- W2060902613 hasConcept C71924100 @default.
- W2060902613 hasConcept C86803240 @default.
- W2060902613 hasConcept C98274493 @default.
- W2060902613 hasConceptScore W2060902613C126322002 @default.
- W2060902613 hasConceptScore W2060902613C134018914 @default.
- W2060902613 hasConceptScore W2060902613C150903083 @default.
- W2060902613 hasConceptScore W2060902613C181199279 @default.
- W2060902613 hasConceptScore W2060902613C185592680 @default.
- W2060902613 hasConceptScore W2060902613C19831878 @default.
- W2060902613 hasConceptScore W2060902613C200886947 @default.
- W2060902613 hasConceptScore W2060902613C202751555 @default.
- W2060902613 hasConceptScore W2060902613C207001950 @default.
- W2060902613 hasConceptScore W2060902613C2780035454 @default.
- W2060902613 hasConceptScore W2060902613C2780091579 @default.
- W2060902613 hasConceptScore W2060902613C29730261 @default.
- W2060902613 hasConceptScore W2060902613C55493867 @default.
- W2060902613 hasConceptScore W2060902613C71924100 @default.
- W2060902613 hasConceptScore W2060902613C86803240 @default.
- W2060902613 hasConceptScore W2060902613C98274493 @default.
- W2060902613 hasLocation W20609026131 @default.
- W2060902613 hasLocation W20609026132 @default.
- W2060902613 hasOpenAccess W2060902613 @default.
- W2060902613 hasPrimaryLocation W20609026131 @default.
- W2060902613 hasRelatedWork W1942105859 @default.
- W2060902613 hasRelatedWork W2008859415 @default.
- W2060902613 hasRelatedWork W2013570490 @default.
- W2060902613 hasRelatedWork W2020959757 @default.
- W2060902613 hasRelatedWork W2042033030 @default.
- W2060902613 hasRelatedWork W2044943066 @default.
- W2060902613 hasRelatedWork W2060902613 @default.
- W2060902613 hasRelatedWork W2070336067 @default.
- W2060902613 hasRelatedWork W2082456910 @default.
- W2060902613 hasRelatedWork W2121675907 @default.
- W2060902613 isParatext "false" @default.
- W2060902613 isRetracted "false" @default.
- W2060902613 magId "2060902613" @default.
- W2060902613 workType "article" @default.