FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060913247> ?p ?o ?g. }

• W2060913247 endingPage "96" @default.
• W2060913247 startingPage "89" @default.
• W2060913247 abstract "Cancer-associated inflammation has been identified as a key determinant of disease progression and survival in colorectal cancer. In particular, it has been consistently reported that both the local and systemic inflammatory responses play an important role in determining outcome in colorectal cancer. Given the importance of cancer-associated inflammation, up-regulation or attenuation of these respective inflammatory responses may be important for progression and survival in colorectal cancer. Recent work has focused on the inter-relationships between the tumour and these key inflammatory processes. In particular, tumour necrosis has been reported to be associated with decreased local inflammatory infiltrate and with elevated markers of systemic inflammation in colorectal cancer and has been proposed as a potential link between the systemic and local inflammatory responses. Thus there is increasing interest in the potential biochemical mediators of this link. In this review we examine the evidence for IL-6 in the natural history of colorectal cancer and its relationship with tumour necrosis and the local and systemic inflammatory responses. There is now good evidence that tumour concentrations of IL-6 have been directly associated with increased necrosis, proliferation, differentiation and vascular invasion, while circulating concentrations of IL-6 are directly associated with T-stage, CRP concentrations and poorer survival. Also, interleukin-6 and down-stream pathways, such as the JAK/STAT pathway, have emerged as important factors in the modulation of cancer-associated inflammation. Therefore, IL-6 has emerged as a key mediator of the relationship between tumour necrosis, local and systemic inflammatory responses and outcome in patients with colorectal cancer." @default.
• W2060913247 created "2016-06-24" @default.
• W2060913247 creator A5036659119 @default.
• W2060913247 creator A5053034355 @default.
• W2060913247 creator A5076087125 @default.
• W2060913247 creator A5086554206 @default.
• W2060913247 date "2013-02-01" @default.
• W2060913247 modified "2023-09-24" @default.
• W2060913247 title "Does interleukin-6 link explain the link between tumour necrosis, local and systemic inflammatory responses and outcome in patients with colorectal cancer?" @default.
• W2060913247 cites W1484344085 @default.
• W2060913247 cites W1652153701 @default.
• W2060913247 cites W1855316965 @default.
• W2060913247 cites W1919907905 @default.
• W2060913247 cites W1945598588 @default.
• W2060913247 cites W1966064580 @default.
• W2060913247 cites W1968643760 @default.
• W2060913247 cites W1970708612 @default.
• W2060913247 cites W1971622516 @default.
• W2060913247 cites W1973355521 @default.
• W2060913247 cites W1978172024 @default.
• W2060913247 cites W1982020196 @default.
• W2060913247 cites W1983591605 @default.
• W2060913247 cites W1984356383 @default.
• W2060913247 cites W1985532701 @default.
• W2060913247 cites W1986434780 @default.
• W2060913247 cites W1986832270 @default.
• W2060913247 cites W1993133962 @default.
• W2060913247 cites W1995143704 @default.
• W2060913247 cites W1995646479 @default.
• W2060913247 cites W2000521517 @default.
• W2060913247 cites W2000619485 @default.
• W2060913247 cites W2000997921 @default.
• W2060913247 cites W2001717792 @default.
• W2060913247 cites W2001740313 @default.
• W2060913247 cites W2004150448 @default.
• W2060913247 cites W2006708761 @default.
• W2060913247 cites W2006751258 @default.
• W2060913247 cites W2007501395 @default.
• W2060913247 cites W2007619928 @default.
• W2060913247 cites W2011532948 @default.
• W2060913247 cites W2012396851 @default.
• W2060913247 cites W2017846490 @default.
• W2060913247 cites W2018498519 @default.
• W2060913247 cites W2018958047 @default.
• W2060913247 cites W2023457562 @default.
• W2060913247 cites W2024573177 @default.
• W2060913247 cites W2025193872 @default.
• W2060913247 cites W2029869458 @default.
• W2060913247 cites W2031687428 @default.
• W2060913247 cites W2032999541 @default.
• W2060913247 cites W2034269086 @default.
• W2060913247 cites W2034681353 @default.
• W2060913247 cites W2037861078 @default.
• W2060913247 cites W2038063798 @default.
• W2060913247 cites W2039321642 @default.
• W2060913247 cites W2039845199 @default.
• W2060913247 cites W2042283860 @default.
• W2060913247 cites W2043103956 @default.
• W2060913247 cites W2043107232 @default.
• W2060913247 cites W2044192395 @default.
• W2060913247 cites W2053243767 @default.
• W2060913247 cites W2053546660 @default.
• W2060913247 cites W2057625648 @default.
• W2060913247 cites W2058372182 @default.
• W2060913247 cites W2058554371 @default.
• W2060913247 cites W2061097847 @default.
• W2060913247 cites W2062750452 @default.
• W2060913247 cites W2063874265 @default.
• W2060913247 cites W2069027997 @default.
• W2060913247 cites W2070968699 @default.
• W2060913247 cites W2074243608 @default.
• W2060913247 cites W2074564761 @default.
• W2060913247 cites W2074601175 @default.
• W2060913247 cites W2078558213 @default.
• W2060913247 cites W2081107312 @default.
• W2060913247 cites W2081991056 @default.
• W2060913247 cites W2082708405 @default.
• W2060913247 cites W2083193799 @default.
• W2060913247 cites W2085866528 @default.
• W2060913247 cites W2088535777 @default.
• W2060913247 cites W2090109598 @default.
• W2060913247 cites W2096571184 @default.
• W2060913247 cites W2097926940 @default.
• W2060913247 cites W2101229561 @default.
• W2060913247 cites W2102144390 @default.
• W2060913247 cites W2103173236 @default.
• W2060913247 cites W2103904089 @default.
• W2060913247 cites W2116496447 @default.
• W2060913247 cites W2117692326 @default.
• W2060913247 cites W2119120508 @default.
• W2060913247 cites W2119911369 @default.
• W2060913247 cites W2123049792 @default.
• W2060913247 cites W2123105952 @default.
• W2060913247 cites W2130024368 @default.
• W2060913247 cites W2132770403 @default.
• W2060913247 cites W2133439754 @default.
• W2060913247 cites W2134272506 @default.
• W2060913247 cites W2139778116 @default.

• next