FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060927358> ?p ?o ?g. }

• W2060927358 endingPage "H691" @default.
• W2060927358 startingPage "H684" @default.
• W2060927358 abstract "We examined the influence of chronic treatment with ANG-(1–7) on development of hypertension and end-organ damage in spontaneously hypertensive rats (SHR) chronically treated with the nitric oxide synthesis inhibitor l-NAME (SHR-l-NAME). l-NAME administered orally (80 mg/l) for 4 wk significantly elevated mean arterial pressure (MAP) compared with SHR controls drinking regular water (269 ± 10 vs. 196 ± 6 mmHg). ANG-(1–7) (24 μg·kg −1 ·h −1 ) or captopril (300 mg/l) significantly attenuated the elevation in MAP due to l-NAME (213 ± 7 and 228 ± 8 mmHg, respectively), and ANG-(1–7) + captopril completely reversed the l-NAME-dependent increase in MAP (193 ± 5 mmHg). l-NAME-induced increases in urinary protein were significantly lower in ANG-(1–7)-treated animals (226 ± 6 vs. 145 ± 12 mg/day). Captopril was more effective (96 ± 12 mg/day), and there was no additional effect of captopril + ANG-(1–7) (87 ± 5 mg/day). The abnormal vascular responsiveness to endothelin-1, carbachol, and sodium nitroprusside in perfused mesenteric vascular bed of SHR-l-NAME was improved by ANG-(1–7) or captopril, with no additive effect of ANG-(1–7) + captopril. In isolated perfused hearts, recovery of left ventricular function from 40 min of global ischemia was significantly better in ANG-(1–7)- or captopril-treated SHR-l-NAME, with additive effects of combined treatment. The beneficial effects of ANG-(1–7) on MAP and cardiac function were inhibited when indomethacin was administered with ANG-(1–7), but indomethacin did not reverse the protective effects on proteinuria or vascular reactivity. The protective effects of the ANG-(1–7) analog AVE-0991 were qualitatively comparable to those of ANG-(1–7) but were not improved over those of captopril alone. Thus, during reduced nitric oxide availability, ANG-(1–7) attenuates development of severe hypertension and end-organ damage; prostaglandins participate in the MAP-lowering and cardioprotective effects of ANG-(1–7); and additive effects of captopril + ANG-(1–7) on MAP, but not proteinuria or endothelial function, suggest common, as well as different, mechanisms of action for the two treatments. Together, the results provide further evidence of a role for ANG-(1–7) in protective effects of angiotensin-converting enzyme inhibition and suggest dissociation of factors influencing MAP and those influencing end-organ damage." @default.
• W2060927358 created "2016-06-24" @default.
• W2060927358 creator A5012210618 @default.
• W2060927358 creator A5034603627 @default.
• W2060927358 creator A5062833068 @default.
• W2060927358 creator A5083308706 @default.
• W2060927358 creator A5089849344 @default.
• W2060927358 date "2006-02-01" @default.
• W2060927358 modified "2023-10-15" @default.
• W2060927358 title "Angiotensin-(1–7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with <scp>l</scp>-NAME" @default.
• W2060927358 cites W1573931014 @default.
• W2060927358 cites W1964547701 @default.
• W2060927358 cites W1971828032 @default.
• W2060927358 cites W1975554421 @default.
• W2060927358 cites W1982261092 @default.
• W2060927358 cites W1991753563 @default.
• W2060927358 cites W2008535164 @default.
• W2060927358 cites W2020449152 @default.
• W2060927358 cites W2041718175 @default.
• W2060927358 cites W2044500356 @default.
• W2060927358 cites W2057694036 @default.
• W2060927358 cites W2058535498 @default.
• W2060927358 cites W2060754299 @default.
• W2060927358 cites W2066971442 @default.
• W2060927358 cites W2067372966 @default.
• W2060927358 cites W2080248232 @default.
• W2060927358 cites W2083529118 @default.
• W2060927358 cites W2084797284 @default.
• W2060927358 cites W2085062315 @default.
• W2060927358 cites W2088575532 @default.
• W2060927358 cites W2089549133 @default.
• W2060927358 cites W2096463273 @default.
• W2060927358 cites W2099901191 @default.
• W2060927358 cites W2103115053 @default.
• W2060927358 cites W2109970626 @default.
• W2060927358 cites W2111572796 @default.
• W2060927358 cites W2112662621 @default.
• W2060927358 cites W2126355774 @default.
• W2060927358 cites W2126820133 @default.
• W2060927358 cites W2130235016 @default.
• W2060927358 cites W2131747794 @default.
• W2060927358 cites W2137225581 @default.
• W2060927358 cites W2137248091 @default.
• W2060927358 cites W2140140902 @default.
• W2060927358 cites W2143722118 @default.
• W2060927358 cites W2146925684 @default.
• W2060927358 cites W2152299939 @default.
• W2060927358 cites W2159872857 @default.
• W2060927358 cites W2160071918 @default.
• W2060927358 cites W2164057428 @default.
• W2060927358 cites W2168664410 @default.
• W2060927358 cites W2283019668 @default.
• W2060927358 cites W2411414038 @default.
• W2060927358 cites W2913696875 @default.
• W2060927358 cites W3016780875 @default.
• W2060927358 doi "https://doi.org/10.1152/ajpheart.00632.2005" @default.
• W2060927358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16403946" @default.
• W2060927358 hasPublicationYear "2006" @default.
• W2060927358 type Work @default.
• W2060927358 sameAs 2060927358 @default.
• W2060927358 citedByCount "168" @default.
• W2060927358 countsByYear W20609273582012 @default.
• W2060927358 countsByYear W20609273582013 @default.
• W2060927358 countsByYear W20609273582014 @default.
• W2060927358 countsByYear W20609273582015 @default.
• W2060927358 countsByYear W20609273582016 @default.
• W2060927358 countsByYear W20609273582017 @default.
• W2060927358 countsByYear W20609273582018 @default.
• W2060927358 countsByYear W20609273582019 @default.
• W2060927358 countsByYear W20609273582020 @default.
• W2060927358 countsByYear W20609273582021 @default.
• W2060927358 countsByYear W20609273582022 @default.
• W2060927358 countsByYear W20609273582023 @default.
• W2060927358 crossrefType "journal-article" @default.
• W2060927358 hasAuthorship W2060927358A5012210618 @default.
• W2060927358 hasAuthorship W2060927358A5034603627 @default.
• W2060927358 hasAuthorship W2060927358A5062833068 @default.
• W2060927358 hasAuthorship W2060927358A5083308706 @default.
• W2060927358 hasAuthorship W2060927358A5089849344 @default.
• W2060927358 hasConcept C126322002 @default.
• W2060927358 hasConcept C134018914 @default.
• W2060927358 hasConcept C144980905 @default.
• W2060927358 hasConcept C170493617 @default.
• W2060927358 hasConcept C27016395 @default.
• W2060927358 hasConcept C2776452961 @default.
• W2060927358 hasConcept C2777953023 @default.
• W2060927358 hasConcept C2778086073 @default.
• W2060927358 hasConcept C2779479957 @default.
• W2060927358 hasConcept C2779610285 @default.
• W2060927358 hasConcept C2908929049 @default.
• W2060927358 hasConcept C519581460 @default.
• W2060927358 hasConcept C71924100 @default.
• W2060927358 hasConcept C84393581 @default.
• W2060927358 hasConceptScore W2060927358C126322002 @default.
• W2060927358 hasConceptScore W2060927358C134018914 @default.
• W2060927358 hasConceptScore W2060927358C144980905 @default.
• W2060927358 hasConceptScore W2060927358C170493617 @default.
• W2060927358 hasConceptScore W2060927358C27016395 @default.

• next