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- W2060947619 abstract "Inoculation of the cornea or footpad with herpes simplex virus Type I (HSV) has been shown to produce subsequent encephalitis or myelitis respectively. Although Schwann cells become infected, there is no destruction or demyelination in the peripheral nervous system (PNS). Demyelination only occurs in the central nervous system. Previous studies have shown that the Schwann cells infected with HSV do not produce enveloped viral particles. The studies presented here demonstrate that microinjection of HSV into the sciatic nerve of mice causes focal mononuclear cell infiltration and demyelination seven days after injection. The Schwann cells in this model produced enveloped virus. These studies demonstrate that when HSV is introduced into the extracellular space of the PNS, demyelination occurs." @default.
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- W2060947619 date "1986-07-01" @default.
- W2060947619 modified "2023-10-14" @default.
- W2060947619 title "Peripheral Nervous System Demyelination with Herpes Simplex Virus" @default.
- W2060947619 doi "https://doi.org/10.1097/00005072-198607000-00004" @default.
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