FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060949085> ?p ?o ?g. }

• W2060949085 endingPage "560" @default.
• W2060949085 startingPage "554" @default.
• W2060949085 abstract "Methylphenidate (Ritalin) is one of the most commonly abused prescription drugs. It is a psychostimulant that inhibits the dopamine and norepinephrine transporters with high affinity. In mice, methylphenidate stimulates locomotor activity, is self-administered, and produces conditioned place preference, typical properties of an addictive drug. We have generated a knockin mouse line bearing a mutant dopamine transporter that is approximately 80-fold less sensitive to cocaine inhibition than wild type. It is interesting to note that this mutant is also almost 50-fold less sensitive to methylphenidate inhibition, suggesting similarities in the binding site for cocaine and methylphenidate. Because methylphenidate is not effective at inhibiting the mutant dopamine transporter, we hypothesized that it would not stimulate locomotor activity or produce reward in the knockin mice. In these knockin mice, doses up to 40 mg/kg methylphenidate either inhibit or fail to stimulate locomotor activity and do not produce conditioned place preference. Doses up to 40 mg/kg methylphenidate also fail to produce stereotypy in the knockin mice. Nisoxetine and desipramine, selective norepinephrine transporter inhibitors, also reduce locomotor activity in wild-type and knockin mice. These results indicate that enhanced dopaminergic neurotransmission is required for methylphenidate9s stimulating and rewarding effects. In addition, we observed that drugs enhancing noradrenergic neurotransmission inhibit locomotor activity in mice, which is consistent with the notion that methylphenidate9s ability to inhibit the norepinephrine transporter may contribute to its efficacy in treating attention deficit hyperactivity disorder." @default.
• W2060949085 created "2016-06-24" @default.
• W2060949085 creator A5027009488 @default.
• W2060949085 creator A5049296125 @default.
• W2060949085 date "2008-08-12" @default.
• W2060949085 modified "2023-09-23" @default.
• W2060949085 title "The Effects of Methylphenidate on Knockin Mice with a Methylphenidate-Resistant Dopamine Transporter" @default.
• W2060949085 cites W1507993982 @default.
• W2060949085 cites W1515432410 @default.
• W2060949085 cites W1754082247 @default.
• W2060949085 cites W1788048136 @default.
• W2060949085 cites W1963735974 @default.
• W2060949085 cites W1964780815 @default.
• W2060949085 cites W1966200243 @default.
• W2060949085 cites W1972018527 @default.
• W2060949085 cites W1972239059 @default.
• W2060949085 cites W1989275850 @default.
• W2060949085 cites W1995992264 @default.
• W2060949085 cites W2005013646 @default.
• W2060949085 cites W2006739617 @default.
• W2060949085 cites W2007935614 @default.
• W2060949085 cites W2012137739 @default.
• W2060949085 cites W2014793858 @default.
• W2060949085 cites W2024382834 @default.
• W2060949085 cites W2033200028 @default.
• W2060949085 cites W2058950808 @default.
• W2060949085 cites W2063288222 @default.
• W2060949085 cites W2064022387 @default.
• W2060949085 cites W2068437842 @default.
• W2060949085 cites W2093851420 @default.
• W2060949085 cites W2095000010 @default.
• W2060949085 cites W2113375740 @default.
• W2060949085 cites W2122592499 @default.
• W2060949085 cites W2125941485 @default.
• W2060949085 cites W2128014576 @default.
• W2060949085 cites W2134340301 @default.
• W2060949085 cites W2148819542 @default.
• W2060949085 cites W2149928224 @default.
• W2060949085 cites W2156566466 @default.
• W2060949085 cites W2163050774 @default.
• W2060949085 cites W2165398609 @default.
• W2060949085 cites W2165964424 @default.
• W2060949085 cites W2312364418 @default.
• W2060949085 cites W2405138604 @default.
• W2060949085 cites W4317523924 @default.
• W2060949085 doi "https://doi.org/10.1124/jpet.108.141713" @default.
• W2060949085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18698001" @default.
• W2060949085 hasPublicationYear "2008" @default.
• W2060949085 type Work @default.
• W2060949085 sameAs 2060949085 @default.
• W2060949085 citedByCount "29" @default.
• W2060949085 countsByYear W20609490852012 @default.
• W2060949085 countsByYear W20609490852013 @default.
• W2060949085 countsByYear W20609490852014 @default.
• W2060949085 countsByYear W20609490852015 @default.
• W2060949085 countsByYear W20609490852016 @default.
• W2060949085 countsByYear W20609490852017 @default.
• W2060949085 countsByYear W20609490852019 @default.
• W2060949085 countsByYear W20609490852020 @default.
• W2060949085 countsByYear W20609490852021 @default.
• W2060949085 crossrefType "journal-article" @default.
• W2060949085 hasAuthorship W2060949085A5027009488 @default.
• W2060949085 hasAuthorship W2060949085A5049296125 @default.
• W2060949085 hasConcept C118552586 @default.
• W2060949085 hasConcept C137183658 @default.
• W2060949085 hasConcept C15744967 @default.
• W2060949085 hasConcept C169760540 @default.
• W2060949085 hasConcept C176233148 @default.
• W2060949085 hasConcept C185592680 @default.
• W2060949085 hasConcept C2776755682 @default.
• W2060949085 hasConcept C2777112843 @default.
• W2060949085 hasConcept C2777193897 @default.
• W2060949085 hasConcept C2778514916 @default.
• W2060949085 hasConcept C2779126938 @default.
• W2060949085 hasConcept C2779177272 @default.
• W2060949085 hasConcept C2780250439 @default.
• W2060949085 hasConcept C2780783007 @default.
• W2060949085 hasConcept C2781161787 @default.
• W2060949085 hasConcept C2909816965 @default.
• W2060949085 hasConcept C35124327 @default.
• W2060949085 hasConcept C513476851 @default.
• W2060949085 hasConcept C86803240 @default.
• W2060949085 hasConcept C98274493 @default.
• W2060949085 hasConceptScore W2060949085C118552586 @default.
• W2060949085 hasConceptScore W2060949085C137183658 @default.
• W2060949085 hasConceptScore W2060949085C15744967 @default.
• W2060949085 hasConceptScore W2060949085C169760540 @default.
• W2060949085 hasConceptScore W2060949085C176233148 @default.
• W2060949085 hasConceptScore W2060949085C185592680 @default.
• W2060949085 hasConceptScore W2060949085C2776755682 @default.
• W2060949085 hasConceptScore W2060949085C2777112843 @default.
• W2060949085 hasConceptScore W2060949085C2777193897 @default.
• W2060949085 hasConceptScore W2060949085C2778514916 @default.
• W2060949085 hasConceptScore W2060949085C2779126938 @default.
• W2060949085 hasConceptScore W2060949085C2779177272 @default.
• W2060949085 hasConceptScore W2060949085C2780250439 @default.
• W2060949085 hasConceptScore W2060949085C2780783007 @default.
• W2060949085 hasConceptScore W2060949085C2781161787 @default.

• next