FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060955024> ?p ?o ?g. }

• W2060955024 endingPage "e8415" @default.
• W2060955024 startingPage "e8415" @default.
• W2060955024 abstract "Changes in whole body energy levels are closely linked to alterations in body weight and bone mass. Here, we show that hypothalamic signals contribute to the regulation of bone mass in a manner consistent with the central perception of energy status. Mice lacking neuropeptide Y (NPY), a well-known orexigenic factor whose hypothalamic expression is increased in fasting, have significantly increased bone mass in association with enhanced osteoblast activity and elevated expression of bone osteogenic transcription factors, Runx2 and Osterix. In contrast, wild type and NPY knockout (NPY −/−) mice in which NPY is specifically over expressed in the hypothalamus (AAV-NPY+) show a significant reduction in bone mass despite developing an obese phenotype. The AAV-NPY+ induced loss of bone mass is consistent with models known to mimic the central effects of fasting, which also show increased hypothalamic NPY levels. Thus these data indicate that, in addition to well characterized responses to body mass, skeletal tissue also responds to the perception of nutritional status by the hypothalamus independently of body weight. In addition, the reduction in bone mass by AAV NPY+ administration does not completely correct the high bone mass phenotype of NPY −/− mice, indicating the possibility that peripheral NPY may also be an important regulator of bone mass. Indeed, we demonstrate the expression of NPY specifically in osteoblasts. In conclusion, these data identifies NPY as a critical integrator of bone homeostatic signals; increasing bone mass during times of obesity when hypothalamic NPY expression levels are low and reducing bone formation to conserve energy under ‘starving’ conditions, when hypothalamic NPY expression levels are high." @default.
• W2060955024 created "2016-06-24" @default.
• W2060955024 creator A5011735451 @default.
• W2060955024 creator A5014099515 @default.
• W2060955024 creator A5018358512 @default.
• W2060955024 creator A5024589971 @default.
• W2060955024 creator A5029220305 @default.
• W2060955024 creator A5030042126 @default.
• W2060955024 creator A5032668574 @default.
• W2060955024 creator A5034555453 @default.
• W2060955024 creator A5049634435 @default.
• W2060955024 creator A5055229683 @default.
• W2060955024 creator A5056280115 @default.
• W2060955024 creator A5064765902 @default.
• W2060955024 creator A5065786104 @default.
• W2060955024 creator A5069378850 @default.
• W2060955024 creator A5071798264 @default.
• W2060955024 creator A5080238392 @default.
• W2060955024 creator A5080737658 @default.
• W2060955024 creator A5081437044 @default.
• W2060955024 creator A5081494160 @default.
• W2060955024 creator A5087374760 @default.
• W2060955024 creator A5087855721 @default.
• W2060955024 creator A5088862018 @default.
• W2060955024 date "2009-12-22" @default.
• W2060955024 modified "2023-10-16" @default.
• W2060955024 title "Neuropeptide Y Knockout Mice Reveal a Central Role of NPY in the Coordination of Bone Mass to Body Weight" @default.
• W2060955024 cites W1522048223 @default.
• W2060955024 cites W1963690512 @default.
• W2060955024 cites W1967608036 @default.
• W2060955024 cites W1996557250 @default.
• W2060955024 cites W2005487416 @default.
• W2060955024 cites W2005491364 @default.
• W2060955024 cites W2012029490 @default.
• W2060955024 cites W2022449949 @default.
• W2060955024 cites W2026982802 @default.
• W2060955024 cites W2028065902 @default.
• W2060955024 cites W2029202516 @default.
• W2060955024 cites W2033305745 @default.
• W2060955024 cites W2054053819 @default.
• W2060955024 cites W2068461519 @default.
• W2060955024 cites W2074571415 @default.
• W2060955024 cites W2080650027 @default.
• W2060955024 cites W2087549132 @default.
• W2060955024 cites W2088865398 @default.
• W2060955024 cites W2089553864 @default.
• W2060955024 cites W2099542131 @default.
• W2060955024 cites W2110117655 @default.
• W2060955024 cites W2118943047 @default.
• W2060955024 cites W2125312207 @default.
• W2060955024 cites W2125354005 @default.
• W2060955024 cites W2133272918 @default.
• W2060955024 cites W2147510409 @default.
• W2060955024 doi "https://doi.org/10.1371/journal.pone.0008415" @default.
• W2060955024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2794533" @default.
• W2060955024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20027231" @default.
• W2060955024 hasPublicationYear "2009" @default.
• W2060955024 type Work @default.
• W2060955024 sameAs 2060955024 @default.
• W2060955024 citedByCount "138" @default.
• W2060955024 countsByYear W20609550242012 @default.
• W2060955024 countsByYear W20609550242013 @default.
• W2060955024 countsByYear W20609550242014 @default.
• W2060955024 countsByYear W20609550242015 @default.
• W2060955024 countsByYear W20609550242016 @default.
• W2060955024 countsByYear W20609550242017 @default.
• W2060955024 countsByYear W20609550242018 @default.
• W2060955024 countsByYear W20609550242019 @default.
• W2060955024 countsByYear W20609550242020 @default.
• W2060955024 countsByYear W20609550242021 @default.
• W2060955024 countsByYear W20609550242022 @default.
• W2060955024 countsByYear W20609550242023 @default.
• W2060955024 crossrefType "journal-article" @default.
• W2060955024 hasAuthorship W2060955024A5011735451 @default.
• W2060955024 hasAuthorship W2060955024A5014099515 @default.
• W2060955024 hasAuthorship W2060955024A5018358512 @default.
• W2060955024 hasAuthorship W2060955024A5024589971 @default.
• W2060955024 hasAuthorship W2060955024A5029220305 @default.
• W2060955024 hasAuthorship W2060955024A5030042126 @default.
• W2060955024 hasAuthorship W2060955024A5032668574 @default.
• W2060955024 hasAuthorship W2060955024A5034555453 @default.
• W2060955024 hasAuthorship W2060955024A5049634435 @default.
• W2060955024 hasAuthorship W2060955024A5055229683 @default.
• W2060955024 hasAuthorship W2060955024A5056280115 @default.
• W2060955024 hasAuthorship W2060955024A5064765902 @default.
• W2060955024 hasAuthorship W2060955024A5065786104 @default.
• W2060955024 hasAuthorship W2060955024A5069378850 @default.
• W2060955024 hasAuthorship W2060955024A5071798264 @default.
• W2060955024 hasAuthorship W2060955024A5080238392 @default.
• W2060955024 hasAuthorship W2060955024A5080737658 @default.
• W2060955024 hasAuthorship W2060955024A5081437044 @default.
• W2060955024 hasAuthorship W2060955024A5081494160 @default.
• W2060955024 hasAuthorship W2060955024A5087374760 @default.
• W2060955024 hasAuthorship W2060955024A5087855721 @default.
• W2060955024 hasAuthorship W2060955024A5088862018 @default.
• W2060955024 hasBestOaLocation W20609550241 @default.
• W2060955024 hasConcept C118303440 @default.
• W2060955024 hasConcept C126322002 @default.

• next