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- W2060957777 abstract "The presence of multiple axon growth inhibitors may partly explain why central nervous system axons are generally incapable of regenerating after injury. Using RNA interference (RNAi) in dorsal root ganglia neurons (DRGN), we demonstrate siRNA-mediated silencing of components of the inhibitory signalling cascade, including p75NTR, NgR and Rho-A mRNA, of 70%, 100% and 100% of the relevant protein, respectively, while changes in neither protein levels nor cellular immunoreactivity were detected using the relevant scrambled siRNA control sequences. Importantly, after 48 h in culture after siRNA-mediated knockdown of Rho-A, neurite outgrowth was enhanced by 30% compared to that after p75NTR and 50% after NgR silencing. By 3 days, a 5-, 3.5- and 6.5-fold increase in betaIII-tubulin protein levels were observed compared to controls without siRNA after knockdown of p75NTR, NgR and Rho-A, respectively. Together, these results suggest that Rho-A knockdown might be the most effective target for a disinhibition strategy to promote CNS axon regeneration in vivo." @default.
- W2060957777 created "2016-06-24" @default.
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- W2060957777 date "2005-03-01" @default.
- W2060957777 modified "2023-09-25" @default.
- W2060957777 title "Disinhibition of neurotrophin-induced dorsal root ganglion cell neurite outgrowth on CNS myelin by siRNA-mediated knockdown of NgR, p75NTR and Rho-A" @default.
- W2060957777 cites W1492663282 @default.
- W2060957777 cites W1500747468 @default.
- W2060957777 cites W1500809101 @default.
- W2060957777 cites W1516174218 @default.
- W2060957777 cites W1549414615 @default.
- W2060957777 cites W1566509581 @default.
- W2060957777 cites W1567217875 @default.
- W2060957777 cites W1575610897 @default.
- W2060957777 cites W1585651720 @default.
- W2060957777 cites W1586855301 @default.
- W2060957777 cites W1592936555 @default.
- W2060957777 cites W1595029695 @default.
- W2060957777 cites W1611419331 @default.
- W2060957777 cites W1826719783 @default.
- W2060957777 cites W1940297232 @default.
- W2060957777 cites W1964947242 @default.
- W2060957777 cites W1967336797 @default.
- W2060957777 cites W1970772856 @default.
- W2060957777 cites W1977841940 @default.
- W2060957777 cites W1985822867 @default.
- W2060957777 cites W1985829219 @default.
- W2060957777 cites W1989291247 @default.
- W2060957777 cites W1990099307 @default.
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- W2060957777 cites W1993933934 @default.
- W2060957777 cites W1994088328 @default.
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- W2060957777 cites W2005001826 @default.
- W2060957777 cites W2020122922 @default.
- W2060957777 cites W2025778924 @default.
- W2060957777 cites W2032304318 @default.
- W2060957777 cites W2034844685 @default.
- W2060957777 cites W2036313068 @default.
- W2060957777 cites W2036782893 @default.
- W2060957777 cites W2047363293 @default.
- W2060957777 cites W2051945956 @default.
- W2060957777 cites W2054336547 @default.
- W2060957777 cites W2056610728 @default.
- W2060957777 cites W2057703191 @default.
- W2060957777 cites W2080306074 @default.
- W2060957777 cites W2082824466 @default.
- W2060957777 cites W2082988090 @default.
- W2060957777 cites W2085893808 @default.
- W2060957777 cites W2088216857 @default.
- W2060957777 cites W2090389580 @default.
- W2060957777 cites W2091236027 @default.
- W2060957777 cites W2091572089 @default.
- W2060957777 cites W2093425928 @default.
- W2060957777 cites W2093814006 @default.
- W2060957777 cites W2096988407 @default.
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- W2060957777 cites W2104907082 @default.
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- W2060957777 cites W2116181102 @default.
- W2060957777 cites W2117406052 @default.
- W2060957777 cites W2118270120 @default.
- W2060957777 cites W2121666423 @default.
- W2060957777 cites W2124308710 @default.
- W2060957777 cites W2125955139 @default.
- W2060957777 cites W2132052155 @default.
- W2060957777 cites W2135908073 @default.
- W2060957777 cites W2139565721 @default.
- W2060957777 cites W2142418508 @default.
- W2060957777 cites W2142847927 @default.
- W2060957777 cites W2149942972 @default.
- W2060957777 cites W2157441732 @default.
- W2060957777 cites W2164325979 @default.
- W2060957777 cites W2164465986 @default.
- W2060957777 cites W2170467038 @default.
- W2060957777 doi "https://doi.org/10.1016/j.mcn.2004.11.002" @default.
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