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- W2060964602 abstract "The continual reassessment method is a recommended dose escalation design for including patients in phase I clinical trials designed to estimate the maximum tolerated dose. However, for a particular trial, the implementation of these methods requires extensive computer programming. Standard 3+3 designs do not require this, but have shown to possess poor statistical properties. np1 is a user friendly computer program which has implemented two continual reassessment methods for simulating and conducting a phase I clinical trial. Several options allow the user to investigate operating characteristics under various scenarios." @default.
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- W2060964602 date "2007-10-01" @default.
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- W2060964602 title "np1: A computer program for dose escalation strategies in phase I clinical trials" @default.
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- W2060964602 doi "https://doi.org/10.1016/j.cmpb.2007.06.006" @default.
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