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• W2060967494 abstract "We aimed to explore whether common allelic variations in the SIRT1 gene were associated with excess body weight in a Chinese cohort. Using standard molecular techniques 820 non-diabetic individuals, some of who were classified as overweight (> 23 Kg/m2), were genotyped for four haplotype-tagged single nucleotide polymorphisms. The rs10509291AA and rs10823116GG genotypes were associated with high body mass index (BMI) > 23 Kg/m2, and the rs7894483TT genotype was associated with lower BMI (< 23 Kg/m2). The rs10509291AT genotype was associated with a modestly higher risk of being overweight, consistent with the presence of an rs10509291A being a dominant or semi-dominant allele. The ATAA (rs7894483/rs10823116) and ATAG haplotypes were associated with a higher risk of being overweight (OR: 17.11 and 5.12) compared with the AAAG haplotype (P <0.01). Thus, the rs10509291, rs7894483, and rs10823116 alleles were associated with a high BMI (> 23 Kg/m2) and with overweight in this non-diabetic Chinese population." @default.
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• W2060967494 date "2012-01-01" @default.
• W2060967494 modified "2023-09-26" @default.
• W2060967494 title "Three single nucleotide variants of the <i>SIRT1</i> gene are associated with overweight in a Chinese population: a case control study" @default.
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• W2060967494 doi "https://doi.org/10.1507/endocrj.ej11-0234" @default.
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