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- W2060977461 abstract "Vertebrate oocytes are naturally arrested at prophase of meiosis I for sustained periods of time before resuming meiosis in a process called oocyte maturation that prepares the egg for fertilization. Members of the constitutively active GPR3/6/12 family of G-protein coupled receptors represent important mediators of meiotic arrest. In the frog oocyte the GPR3/12 homolog GPRx (renamed GPR185) has been shown to sustain meiotic arrest by increasing intracellular cAMP levels through GαSβγ. Here we show that GPRx is enriched at the cell membrane (~80%), recycles through an endosomal compartment at steady state, and loses its ability to signal once trapped intracellularly. Progesterone-mediated oocyte maturation is associated with significant internalization of both endogenous and overexpressed GPRx. Furthermore, a GPRx mutant that does not internalize in response to progesterone is significantly more efficient than wild-type GPRx at blocking oocyte maturation. Collectively our results argue that internalization of the constitutively active GPRx is important to release oocyte meiotic arrest." @default.
- W2060977461 created "2016-06-24" @default.
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- W2060977461 creator A5073846446 @default.
- W2060977461 date "2014-11-01" @default.
- W2060977461 modified "2023-10-18" @default.
- W2060977461 title "Role for endocytosis of a constitutively active GPCR (GPR185) in releasing vertebrate oocyte meiotic arrest" @default.
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- W2060977461 doi "https://doi.org/10.1016/j.ydbio.2014.08.036" @default.
- W2060977461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25220151" @default.
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