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- W2060978262 abstract "Inhibition of tissue factor/factor VIIa complex (TF/FVIIa) is an attractive strategy for antithrombotic therapies. We began with an investigation of a non-amidine TF/FVIIa inhibitor based on a modification of amidine compound 1. Optimization of the substituents on the P1 phenyl portion of the compound 1 led to a neutral or less basic alternative for the 4-amidinophenyl moiety. By further optimization of the substituents on the central phenyl ring, a highly potent and selective TF/FVIIa inhibitor 17d was discovered." @default.
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- W2060978262 date "2006-12-01" @default.
- W2060978262 modified "2023-09-28" @default.
- W2060978262 title "Potent and selective TF/FVIIa inhibitors containing a neutral P1 ligand" @default.
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- W2060978262 doi "https://doi.org/10.1016/j.bmc.2006.08.010" @default.
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