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- W2060993125 abstract "The latent reservoir for HIV-1 in resting CD4(+) T cells remains a major barrier to HIV-1 eradication, even though highly active antiretroviral therapy (HAART) can successfully reduce plasma HIV-1 levels to below the detection limit of clinical assays and reverse disease progression. Proposed eradication strategies involve reactivation of this latent reservoir. Multiple mechanisms are believed to be involved in maintaining HIV-1 latency, mostly through suppression of transcription. These include cytoplasmic sequestration of host transcription factors and epigenetic modifications such as histone deacetylation, histone methylation and DNA methylation. Therefore, strategies targeting these mechanisms have been explored for reactivation of the latent reservoir. In this review, we discuss current pharmacological approaches toward eradication, focusing on small molecule latency-reversing agents, their mechanisms, advantages and limitations." @default.
- W2060993125 created "2016-06-24" @default.
- W2060993125 creator A5013307232 @default.
- W2060993125 creator A5079324608 @default.
- W2060993125 date "2013-06-01" @default.
- W2060993125 modified "2023-09-27" @default.
- W2060993125 title "Targeting HIV latency: pharmacologic strategies toward eradication" @default.
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- W2060993125 doi "https://doi.org/10.1016/j.drudis.2012.12.008" @default.
- W2060993125 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3672351" @default.
- W2060993125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23270785" @default.
- W2060993125 hasPublicationYear "2013" @default.
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