FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060996862> ?p ?o ?g. }

• W2060996862 endingPage "103" @default.
• W2060996862 startingPage "93" @default.
• W2060996862 abstract "Paraquat (PQ), a broad spectrum herbicide, produces severe lung inflammation and necrosis resulting in pulmonary fibrosis and respiratory failure. Tachykinins are peptides released by sensory C fibers and have the ability of influencing respiratory functions and cellular proliferation. To examine whether the damage caused by PQ involves tachykinins, rats were depleted in their content of tachykinins by systemic treatment with capsaicin prior to PQ exposure. The animal subjected to this treatment showed a 3-fold higher viability compared to those treated with PQ alone (75 vs 27%). Depletion of reduced glutathione (GSH) is associated with oxidative stress produced by reactive oxygen intermediates during PQ metabolism. This is considered to be critical in the pathogenesis of lung damage by PQ. PQ treatment induced a significant depletion of GSH during the first days and a similar effect was also observed in the group of capsaicin-pretreated rats. Four weeks after PQ treatment the levels of GSH were similar to controls in rat pretreated or not with capsaicin plus PQ. This may indicate that the reduced levels of GSH may be associated to the toxicity observed in the acute phase, but not of importance in the final PQ-induced mortality. Neutral endopeptidase (NEP) is an enzyme considered to be critical in controlling the levels of tachykinins. Exposure of crude membrane preparations of rat lung to PQ resulted in a dose-dependent inhibition of NEP activity. Since NEP inactivation may occur in lung following a PQ exposure in vivo, the results indicate that during PQ intoxication a more sustained activity of tachykinins may be present, producing effects such as cell proliferation, fluid extravasation and bronchoconstriction. In conclusion, this finding supports the hypothesis that neuropeptides released from capsaicin-sensitive nerves could be involved in the modulation of PQ-induced lung damage." @default.
• W2060996862 created "2016-06-24" @default.
• W2060996862 creator A5004989591 @default.
• W2060996862 creator A5017357258 @default.
• W2060996862 creator A5047628421 @default.
• W2060996862 creator A5051332021 @default.
• W2060996862 creator A5074398026 @default.
• W2060996862 creator A5079358204 @default.
• W2060996862 creator A5080873687 @default.
• W2060996862 date "1998-11-01" @default.
• W2060996862 modified "2023-09-27" @default.
• W2060996862 title "Involvement of capsaicin-sensitive nerves in paraquat-induced mortality" @default.
• W2060996862 cites W1968549810 @default.
• W2060996862 cites W1980037780 @default.
• W2060996862 cites W2005736754 @default.
• W2060996862 cites W2006370393 @default.
• W2060996862 cites W2016919586 @default.
• W2060996862 cites W2020842224 @default.
• W2060996862 cites W2030774561 @default.
• W2060996862 cites W2046296312 @default.
• W2060996862 cites W2047920764 @default.
• W2060996862 cites W2060843858 @default.
• W2060996862 cites W2066461253 @default.
• W2060996862 cites W2068155648 @default.
• W2060996862 cites W2086578818 @default.
• W2060996862 cites W2087354425 @default.
• W2060996862 cites W2102131116 @default.
• W2060996862 cites W2116315384 @default.
• W2060996862 cites W2160894539 @default.
• W2060996862 cites W2346872788 @default.
• W2060996862 cites W2399318827 @default.
• W2060996862 cites W2410904924 @default.
• W2060996862 cites W2440986721 @default.
• W2060996862 cites W52405248 @default.
• W2060996862 cites W66536903 @default.
• W2060996862 cites W2086430171 @default.
• W2060996862 cites W3112457990 @default.
• W2060996862 doi "https://doi.org/10.1016/s0009-2797(98)00080-5" @default.
• W2060996862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9877203" @default.
• W2060996862 hasPublicationYear "1998" @default.
• W2060996862 type Work @default.
• W2060996862 sameAs 2060996862 @default.
• W2060996862 citedByCount "3" @default.
• W2060996862 countsByYear W20609968622016 @default.
• W2060996862 crossrefType "journal-article" @default.
• W2060996862 hasAuthorship W2060996862A5004989591 @default.
• W2060996862 hasAuthorship W2060996862A5017357258 @default.
• W2060996862 hasAuthorship W2060996862A5047628421 @default.
• W2060996862 hasAuthorship W2060996862A5051332021 @default.
• W2060996862 hasAuthorship W2060996862A5074398026 @default.
• W2060996862 hasAuthorship W2060996862A5079358204 @default.
• W2060996862 hasAuthorship W2060996862A5080873687 @default.
• W2060996862 hasConcept C170493617 @default.
• W2060996862 hasConcept C178790620 @default.
• W2060996862 hasConcept C181199279 @default.
• W2060996862 hasConcept C185592680 @default.
• W2060996862 hasConcept C2776151105 @default.
• W2060996862 hasConcept C2776527163 @default.
• W2060996862 hasConcept C2780051329 @default.
• W2060996862 hasConcept C29730261 @default.
• W2060996862 hasConcept C48349386 @default.
• W2060996862 hasConcept C538909803 @default.
• W2060996862 hasConcept C55493867 @default.
• W2060996862 hasConcept C86803240 @default.
• W2060996862 hasConcept C98274493 @default.
• W2060996862 hasConceptScore W2060996862C170493617 @default.
• W2060996862 hasConceptScore W2060996862C178790620 @default.
• W2060996862 hasConceptScore W2060996862C181199279 @default.
• W2060996862 hasConceptScore W2060996862C185592680 @default.
• W2060996862 hasConceptScore W2060996862C2776151105 @default.
• W2060996862 hasConceptScore W2060996862C2776527163 @default.
• W2060996862 hasConceptScore W2060996862C2780051329 @default.
• W2060996862 hasConceptScore W2060996862C29730261 @default.
• W2060996862 hasConceptScore W2060996862C48349386 @default.
• W2060996862 hasConceptScore W2060996862C538909803 @default.
• W2060996862 hasConceptScore W2060996862C55493867 @default.
• W2060996862 hasConceptScore W2060996862C86803240 @default.
• W2060996862 hasConceptScore W2060996862C98274493 @default.
• W2060996862 hasIssue "1-2" @default.
• W2060996862 hasLocation W20609968621 @default.
• W2060996862 hasLocation W20609968622 @default.
• W2060996862 hasOpenAccess W2060996862 @default.
• W2060996862 hasPrimaryLocation W20609968621 @default.
• W2060996862 hasRelatedWork W1993194916 @default.
• W2060996862 hasRelatedWork W2052122421 @default.
• W2060996862 hasRelatedWork W2076134807 @default.
• W2060996862 hasRelatedWork W2149460060 @default.
• W2060996862 hasRelatedWork W2163338807 @default.
• W2060996862 hasRelatedWork W2377341619 @default.
• W2060996862 hasRelatedWork W2587676932 @default.
• W2060996862 hasRelatedWork W2765590223 @default.
• W2060996862 hasRelatedWork W2982127316 @default.
• W2060996862 hasRelatedWork W98214784 @default.
• W2060996862 hasVolume "116" @default.
• W2060996862 isParatext "false" @default.
• W2060996862 isRetracted "false" @default.
• W2060996862 magId "2060996862" @default.
• W2060996862 workType "article" @default.