FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061003414> ?p ?o ?g. }

• W2061003414 endingPage "e85863" @default.
• W2061003414 startingPage "e85863" @default.
• W2061003414 abstract "In ataxia-telangiectasia (A-T) the death of neurons is associated with the loss of neuronal cell cycle control. In most Atm(-/-) mouse models, however, these cell cycle anomalies are present but the phenotype of neuronal cell loss found in humans is not. Mouse Atm(-/-) neurons re-enter a cell cycle and replicate their DNA, but they do not die--even months after initiating the cycle. In the current study, we explore whether systemic inflammation or hypoxia-induced oxidative stress can serve as second stressors that can promote cell death in ATM-deficient neurons. We find that after either immune or hypoxic challenge, the levels of cell cycle proteins--PCNA, cyclin A and cyclin B--are significantly elevated in cerebellar Purkinje cells. Both the number of cells that express cell cycle proteins as well as the intensity of the expression levels in each cell is increased in the stressed animals. The cell cycle-positive neurons also increasingly express cell death markers such as activated caspase-3, γ-H2AX and TUNEL staining. Interestingly, nuclear HDAC4 localization is also enhanced in Atm(-/-) Purkinje neurons after the immune challenge suggesting that both genetic and epigenetic changes in Atm(-/-) mice respond to environmental challenges. Our findings support the hypothesis that multiple insults are needed to drive even genetically vulnerable neurons to die a cell cycle-related cell death and point to either inflammation or oxidative stressors as potential contributors to the A-T disease process." @default.
• W2061003414 created "2016-06-24" @default.
• W2061003414 creator A5015097400 @default.
• W2061003414 creator A5019963761 @default.
• W2061003414 creator A5061088955 @default.
• W2061003414 creator A5084208504 @default.
• W2061003414 date "2014-01-20" @default.
• W2061003414 modified "2023-10-14" @default.
• W2061003414 title "The Interaction of the Atm Genotype with Inflammation and Oxidative Stress" @default.
• W2061003414 cites W1479769602 @default.
• W2061003414 cites W1853857034 @default.
• W2061003414 cites W1970965314 @default.
• W2061003414 cites W1976445933 @default.
• W2061003414 cites W1977861446 @default.
• W2061003414 cites W1985039849 @default.
• W2061003414 cites W1987319516 @default.
• W2061003414 cites W2009102898 @default.
• W2061003414 cites W2011349107 @default.
• W2061003414 cites W2019420937 @default.
• W2061003414 cites W2033599203 @default.
• W2061003414 cites W2033674626 @default.
• W2061003414 cites W2034239110 @default.
• W2061003414 cites W2039390013 @default.
• W2061003414 cites W2043490836 @default.
• W2061003414 cites W2046589688 @default.
• W2061003414 cites W2057119181 @default.
• W2061003414 cites W2060917950 @default.
• W2061003414 cites W2067740947 @default.
• W2061003414 cites W2077858999 @default.
• W2061003414 cites W2080394117 @default.
• W2061003414 cites W2081655354 @default.
• W2061003414 cites W2082969663 @default.
• W2061003414 cites W2087367816 @default.
• W2061003414 cites W2095143211 @default.
• W2061003414 cites W2098053278 @default.
• W2061003414 cites W2100384307 @default.
• W2061003414 cites W2112949011 @default.
• W2061003414 cites W2116784956 @default.
• W2061003414 cites W2117532763 @default.
• W2061003414 cites W2120886826 @default.
• W2061003414 cites W2122405873 @default.
• W2061003414 cites W2123446167 @default.
• W2061003414 cites W2126289901 @default.
• W2061003414 cites W2129449870 @default.
• W2061003414 cites W2131607023 @default.
• W2061003414 cites W2148534836 @default.
• W2061003414 cites W2154566941 @default.
• W2061003414 cites W2155815888 @default.
• W2061003414 cites W2158225056 @default.
• W2061003414 cites W4234317413 @default.
• W2061003414 cites W4237840816 @default.
• W2061003414 doi "https://doi.org/10.1371/journal.pone.0085863" @default.
• W2061003414 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3896418" @default.
• W2061003414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24465754" @default.
• W2061003414 hasPublicationYear "2014" @default.
• W2061003414 type Work @default.
• W2061003414 sameAs 2061003414 @default.
• W2061003414 citedByCount "34" @default.
• W2061003414 countsByYear W20610034142014 @default.
• W2061003414 countsByYear W20610034142015 @default.
• W2061003414 countsByYear W20610034142016 @default.
• W2061003414 countsByYear W20610034142017 @default.
• W2061003414 countsByYear W20610034142018 @default.
• W2061003414 countsByYear W20610034142019 @default.
• W2061003414 countsByYear W20610034142020 @default.
• W2061003414 countsByYear W20610034142021 @default.
• W2061003414 countsByYear W20610034142022 @default.
• W2061003414 countsByYear W20610034142023 @default.
• W2061003414 crossrefType "journal-article" @default.
• W2061003414 hasAuthorship W2061003414A5015097400 @default.
• W2061003414 hasAuthorship W2061003414A5019963761 @default.
• W2061003414 hasAuthorship W2061003414A5061088955 @default.
• W2061003414 hasAuthorship W2061003414A5084208504 @default.
• W2061003414 hasBestOaLocation W20610034141 @default.
• W2061003414 hasConcept C105696609 @default.
• W2061003414 hasConcept C134018914 @default.
• W2061003414 hasConcept C143425029 @default.
• W2061003414 hasConcept C190283241 @default.
• W2061003414 hasConcept C203014093 @default.
• W2061003414 hasConcept C2776151105 @default.
• W2061003414 hasConcept C2776914184 @default.
• W2061003414 hasConcept C2911011838 @default.
• W2061003414 hasConcept C29537977 @default.
• W2061003414 hasConcept C31573885 @default.
• W2061003414 hasConcept C54355233 @default.
• W2061003414 hasConcept C552990157 @default.
• W2061003414 hasConcept C86803240 @default.
• W2061003414 hasConcept C95444343 @default.
• W2061003414 hasConceptScore W2061003414C105696609 @default.
• W2061003414 hasConceptScore W2061003414C134018914 @default.
• W2061003414 hasConceptScore W2061003414C143425029 @default.
• W2061003414 hasConceptScore W2061003414C190283241 @default.
• W2061003414 hasConceptScore W2061003414C203014093 @default.
• W2061003414 hasConceptScore W2061003414C2776151105 @default.
• W2061003414 hasConceptScore W2061003414C2776914184 @default.
• W2061003414 hasConceptScore W2061003414C2911011838 @default.
• W2061003414 hasConceptScore W2061003414C29537977 @default.
• W2061003414 hasConceptScore W2061003414C31573885 @default.

• next