Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061004073> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2061004073 endingPage "11268" @default.
- W2061004073 startingPage "11261" @default.
- W2061004073 abstract "The interferon alpha receptor is composed of two subunits: IFNaR1 and IFNaR2. Interferon alpha binding to the receptor induces phosphorylation of tyrosine 466 on IFNaR1, which in turn binds the SH2 domain of the latent transcription factor Stat2 to initiate signaling. Stat2 also binds to IFNaR2 in a constitutive, phosphorylation-independent manner. To explore the function of the Stat2−IFNaR2 interaction and its possible relationship to the SH2-dependent docking of Stat2 to phosphorylated IFNaR1, the affinity of Stat2 for each of the receptor subunits was determined. Recombinant proteins corresponding to the cytoplasmic domains of the receptor subunits and the central core region of Stat2 were partially purified and used in affinity precipitation experiments to demonstrate that Stat2 binds more avidly to IFNaR2 than to phosphorylated IFNaR1. Surface plasmon resonance based biosensor analysis confirmed this finding; Stat2 bound IFNaR2 (Kd = 45 nM) approximately 6-fold stronger than it bound tyrosine 466-phosphorylated IFNaR1 (Kd = 245 nM). Affinity precipitation experiments involving all three proteins (Stat2, phosphorylated IFNaR1, and IFNaR2) indicated that the Stat2−receptor interactions are independent of one another. The relevance of these data to possible models of interferon alpha signal transduction is discussed." @default.
- W2061004073 created "2016-06-24" @default.
- W2061004073 creator A5066862339 @default.
- W2061004073 creator A5082420788 @default.
- W2061004073 creator A5082427307 @default.
- W2061004073 date "2002-08-21" @default.
- W2061004073 modified "2023-10-17" @default.
- W2061004073 title "Affinity of Stat2 for the Subunits of the Interferon Alpha Receptor" @default.
- W2061004073 doi "https://doi.org/10.1021/bi025913f" @default.
- W2061004073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12220192" @default.
- W2061004073 hasPublicationYear "2002" @default.
- W2061004073 type Work @default.
- W2061004073 sameAs 2061004073 @default.
- W2061004073 citedByCount "13" @default.
- W2061004073 countsByYear W20610040732012 @default.
- W2061004073 countsByYear W20610040732020 @default.
- W2061004073 countsByYear W20610040732021 @default.
- W2061004073 countsByYear W20610040732022 @default.
- W2061004073 crossrefType "journal-article" @default.
- W2061004073 hasAuthorship W2061004073A5066862339 @default.
- W2061004073 hasAuthorship W2061004073A5082420788 @default.
- W2061004073 hasAuthorship W2061004073A5082427307 @default.
- W2061004073 hasConcept C11960822 @default.
- W2061004073 hasConcept C144174609 @default.
- W2061004073 hasConcept C153911025 @default.
- W2061004073 hasConcept C170493617 @default.
- W2061004073 hasConcept C171958077 @default.
- W2061004073 hasConcept C185592680 @default.
- W2061004073 hasConcept C197153747 @default.
- W2061004073 hasConcept C2775960820 @default.
- W2061004073 hasConcept C2776165026 @default.
- W2061004073 hasConcept C2776178377 @default.
- W2061004073 hasConcept C2776239193 @default.
- W2061004073 hasConcept C2777553839 @default.
- W2061004073 hasConcept C2778923194 @default.
- W2061004073 hasConcept C2909179924 @default.
- W2061004073 hasConcept C54355233 @default.
- W2061004073 hasConcept C55493867 @default.
- W2061004073 hasConcept C56165258 @default.
- W2061004073 hasConcept C62478195 @default.
- W2061004073 hasConcept C86803240 @default.
- W2061004073 hasConcept C95444343 @default.
- W2061004073 hasConceptScore W2061004073C11960822 @default.
- W2061004073 hasConceptScore W2061004073C144174609 @default.
- W2061004073 hasConceptScore W2061004073C153911025 @default.
- W2061004073 hasConceptScore W2061004073C170493617 @default.
- W2061004073 hasConceptScore W2061004073C171958077 @default.
- W2061004073 hasConceptScore W2061004073C185592680 @default.
- W2061004073 hasConceptScore W2061004073C197153747 @default.
- W2061004073 hasConceptScore W2061004073C2775960820 @default.
- W2061004073 hasConceptScore W2061004073C2776165026 @default.
- W2061004073 hasConceptScore W2061004073C2776178377 @default.
- W2061004073 hasConceptScore W2061004073C2776239193 @default.
- W2061004073 hasConceptScore W2061004073C2777553839 @default.
- W2061004073 hasConceptScore W2061004073C2778923194 @default.
- W2061004073 hasConceptScore W2061004073C2909179924 @default.
- W2061004073 hasConceptScore W2061004073C54355233 @default.
- W2061004073 hasConceptScore W2061004073C55493867 @default.
- W2061004073 hasConceptScore W2061004073C56165258 @default.
- W2061004073 hasConceptScore W2061004073C62478195 @default.
- W2061004073 hasConceptScore W2061004073C86803240 @default.
- W2061004073 hasConceptScore W2061004073C95444343 @default.
- W2061004073 hasIssue "37" @default.
- W2061004073 hasLocation W20610040731 @default.
- W2061004073 hasLocation W20610040732 @default.
- W2061004073 hasOpenAccess W2061004073 @default.
- W2061004073 hasPrimaryLocation W20610040731 @default.
- W2061004073 hasRelatedWork W1644328688 @default.
- W2061004073 hasRelatedWork W1976402706 @default.
- W2061004073 hasRelatedWork W2000348274 @default.
- W2061004073 hasRelatedWork W2068747852 @default.
- W2061004073 hasRelatedWork W2083733004 @default.
- W2061004073 hasRelatedWork W2230961746 @default.
- W2061004073 hasRelatedWork W2412892123 @default.
- W2061004073 hasRelatedWork W2581276725 @default.
- W2061004073 hasRelatedWork W3217145212 @default.
- W2061004073 hasRelatedWork W4313376294 @default.
- W2061004073 hasVolume "41" @default.
- W2061004073 isParatext "false" @default.
- W2061004073 isRetracted "false" @default.
- W2061004073 magId "2061004073" @default.
- W2061004073 workType "article" @default.