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• W2061033181 abstract "The neurotensin receptor subtype 1 (NTS1) represents an attractive molecular target for imaging various tumors. Positron emission tomography (PET) gained widespread importance due to its sensitivity. We combined the design of a metabolically stable neurotensin analogue with a (68)Ga-radiolabeling approach. The (68)Ga-labeled peptoid-peptide hybrid [(68)Ga]3 revealed high stability, specific tumor uptake (0.7%ID/g, 65 min p.i.), and advantageous biokinetics in vivo using HT29 tumor-bearing nude mice. Because of the ability to internalize into NTS1-expressing tumor cells, [(68)Ga]3 proved to be highly suitable for a reliable and practical visualization of NTS1-expressing tumors in vivo by small animal PET." @default.
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• W2061033181 date "2010-05-21" @default.
• W2061033181 modified "2023-09-23" @default.
• W2061033181 title "Synthesis of a ⁶⁸Ga-Labeled Peptoid−Peptide Hybrid for Imaging of Neurotensin Receptor Expression in Vivo" @default.
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• W2061033181 doi "https://doi.org/10.1021/ml1000728" @default.
• W2061033181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4007950" @default.
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