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- W2061033950 abstract "Cyclic AMP response element binding protein (CREB) is often dysregulated in cancer cells and is an attractive cancer drug target. Previously, we described naphthol AS-E (1) as a small molecule inhibitor of CREB-mediated gene transcription. To understand its bioactive conformation, a series of conformationally constrained analogues of 1 were designed and synthesized. Biological evaluation of these analogues suggests that the global energy minimum of 1 is the likely bioactive conformation." @default.
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- W2061033950 date "2012-04-09" @default.
- W2061033950 modified "2023-09-27" @default.
- W2061033950 title "Design, Synthesis, and Biological Evaluation of Conformationally Constrained Analogues of Naphthol AS-E as Inhibitors of CREB-Mediated Gene Transcription" @default.
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- W2061033950 doi "https://doi.org/10.1021/jm300043c" @default.
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