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- W2061034372 abstract "In a small clinical trial, a new therapeutic approach was studied, whether naloxone, in high dosage over a prolonged period of time, will attenuate withdrawal symptoms in acute opiate detoxification. Six opiate addicts, satisfying DSM III-R criteria of opiate dependence, were given 10mg naloxone under short barbiturate anaesthesia, followed by repeated doses of 0.4mg/h naloxone for at least 72 h. Acute onset of withdrawal symptoms brought about a high dose of naloxone could be suppressed by the short barbiturate anaesthetic; neither continuous supply nor cessation of the naloxone regimen after 96 h caused any severe withdrawal symptoms. Morphine and naloxone measurements in blood at the start of naloxone therapy enabled pharmacokinetic explanations for this paradoxical action of naloxone to be excluded." @default.
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- W2061034372 date "1989-01-01" @default.
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- W2061034372 title "Continuous naloxone administration suppresses opiate withdrawal symptoms in human opiate addicts during detoxification treatment" @default.
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- W2061034372 doi "https://doi.org/10.1016/0022-3956(89)90020-4" @default.
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