Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061035786> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2061035786 endingPage "95" @default.
- W2061035786 startingPage "89" @default.
- W2061035786 abstract "The effects of hormones and dietary factors on rat liver β-hydroxy-β-methylglutaryl coenzyme A reductase activity and serum and liver cholesterol levels were tested. Cholestyramine feeding markedly stimulated reductase activity in the livers of rats depleted of insulin or l-triiodothyronine. Therefore, these hormones are not absolute requirements for the stimulation of reductase activity. In hypophysectomized rats, l-triiodothyronine markedly stimulated reductase activity, even when the animals were cholesterol fed or fasted. However, this stimulation was accompanied by a reduction of serum and liver cholesterol levels. In diabetic rats, insulin failed to either stimulate reductase activity after cholesterol feeding, or to depress the level of liver cholesterol. These results are consistent with a model in which cholesterol functions as a feedback repressor of reductase activity. In contrast, a number of dietary and hormonal states produced little or no change in the level of serum and liver cholesterol while producing widely different reductase activities. These results suggest that the cholesterol level does not regulate reductase activity and cholesterol synthesis and that the factors that affect the formation of cholesterol also have a similar effect on its degradation. However, the possibility of a small subcellular pool of cholesterol regulating reductase activity and thus showing a positive correlation cannot be ruled out. The results reported in this paper suggest that the repressor, in a feedback repression model of regulation, should have similar effects on the rate-limiting enzymes of cholesterol synthesis and degradation. In this way a factor that operates through the repressor affects the rates of synthesis and degradation, but not the level of liver and serum cholesterol." @default.
- W2061035786 created "2016-06-24" @default.
- W2061035786 creator A5017506642 @default.
- W2061035786 creator A5019542004 @default.
- W2061035786 creator A5029059671 @default.
- W2061035786 creator A5052516516 @default.
- W2061035786 creator A5083506106 @default.
- W2061035786 date "1975-05-01" @default.
- W2061035786 modified "2023-09-29" @default.
- W2061035786 title "Regulation of rat liver β-hydroxy-β-methylglutaryl coenzyme A reductase activity and cholesterol levels of serum and liver in various dietary and hormonal states" @default.
- W2061035786 cites W1497990315 @default.
- W2061035786 cites W1500418591 @default.
- W2061035786 cites W1556961288 @default.
- W2061035786 cites W1584638689 @default.
- W2061035786 cites W1657253956 @default.
- W2061035786 cites W1966196964 @default.
- W2061035786 cites W1970405533 @default.
- W2061035786 cites W1974405630 @default.
- W2061035786 cites W1980455986 @default.
- W2061035786 cites W1997079360 @default.
- W2061035786 cites W2006219948 @default.
- W2061035786 cites W2017317049 @default.
- W2061035786 cites W2018519770 @default.
- W2061035786 cites W2037232177 @default.
- W2061035786 cites W2073167703 @default.
- W2061035786 cites W2104010651 @default.
- W2061035786 cites W2115408217 @default.
- W2061035786 cites W2345770204 @default.
- W2061035786 cites W2465382919 @default.
- W2061035786 cites W2467413261 @default.
- W2061035786 cites W2928024704 @default.
- W2061035786 doi "https://doi.org/10.1016/0003-9861(75)90231-3" @default.
- W2061035786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1137403" @default.
- W2061035786 hasPublicationYear "1975" @default.
- W2061035786 type Work @default.
- W2061035786 sameAs 2061035786 @default.
- W2061035786 citedByCount "31" @default.
- W2061035786 crossrefType "journal-article" @default.
- W2061035786 hasAuthorship W2061035786A5017506642 @default.
- W2061035786 hasAuthorship W2061035786A5019542004 @default.
- W2061035786 hasAuthorship W2061035786A5029059671 @default.
- W2061035786 hasAuthorship W2061035786A5052516516 @default.
- W2061035786 hasAuthorship W2061035786A5083506106 @default.
- W2061035786 hasConcept C104788683 @default.
- W2061035786 hasConcept C104950815 @default.
- W2061035786 hasConcept C126322002 @default.
- W2061035786 hasConcept C134018914 @default.
- W2061035786 hasConcept C134651460 @default.
- W2061035786 hasConcept C181199279 @default.
- W2061035786 hasConcept C24998067 @default.
- W2061035786 hasConcept C2777320049 @default.
- W2061035786 hasConcept C2778163477 @default.
- W2061035786 hasConcept C2778697171 @default.
- W2061035786 hasConcept C2779123261 @default.
- W2061035786 hasConcept C2779306644 @default.
- W2061035786 hasConcept C55493867 @default.
- W2061035786 hasConcept C71315377 @default.
- W2061035786 hasConcept C71924100 @default.
- W2061035786 hasConcept C86803240 @default.
- W2061035786 hasConceptScore W2061035786C104788683 @default.
- W2061035786 hasConceptScore W2061035786C104950815 @default.
- W2061035786 hasConceptScore W2061035786C126322002 @default.
- W2061035786 hasConceptScore W2061035786C134018914 @default.
- W2061035786 hasConceptScore W2061035786C134651460 @default.
- W2061035786 hasConceptScore W2061035786C181199279 @default.
- W2061035786 hasConceptScore W2061035786C24998067 @default.
- W2061035786 hasConceptScore W2061035786C2777320049 @default.
- W2061035786 hasConceptScore W2061035786C2778163477 @default.
- W2061035786 hasConceptScore W2061035786C2778697171 @default.
- W2061035786 hasConceptScore W2061035786C2779123261 @default.
- W2061035786 hasConceptScore W2061035786C2779306644 @default.
- W2061035786 hasConceptScore W2061035786C55493867 @default.
- W2061035786 hasConceptScore W2061035786C71315377 @default.
- W2061035786 hasConceptScore W2061035786C71924100 @default.
- W2061035786 hasConceptScore W2061035786C86803240 @default.
- W2061035786 hasIssue "1" @default.
- W2061035786 hasLocation W20610357861 @default.
- W2061035786 hasLocation W20610357862 @default.
- W2061035786 hasOpenAccess W2061035786 @default.
- W2061035786 hasPrimaryLocation W20610357861 @default.
- W2061035786 hasRelatedWork W1728203356 @default.
- W2061035786 hasRelatedWork W1979660213 @default.
- W2061035786 hasRelatedWork W1994371180 @default.
- W2061035786 hasRelatedWork W2013662683 @default.
- W2061035786 hasRelatedWork W2015420935 @default.
- W2061035786 hasRelatedWork W2044724235 @default.
- W2061035786 hasRelatedWork W2079114853 @default.
- W2061035786 hasRelatedWork W2089640559 @default.
- W2061035786 hasRelatedWork W2170397785 @default.
- W2061035786 hasRelatedWork W2419267943 @default.
- W2061035786 hasVolume "168" @default.
- W2061035786 isParatext "false" @default.
- W2061035786 isRetracted "false" @default.
- W2061035786 magId "2061035786" @default.
- W2061035786 workType "article" @default.