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• W2061037159 abstract "In cloned osteoblast‐like cells, MC3T3‐E1, 12‐ O ‐tetradecanoylphorbol‐13‐acetate (TPA), a protein kinase C activating phorbol ester, and 1‐oleoyl‐2‐acetylglycerol (OAG), a specific activator for protein kinase C, stimulated DNA synthesis in a dose‐dependent manner. Both TPA and OAG acted synergistically with insulin‐like growth factor I to stimulate DNA synthesis. TPA as well as OAG suppressed the increase in alkaline phosphatase activity of MC3T3‐E1 cells induced by parathyroid hormone. These results suggest that protein kinase C is involved in the process which directs osteoblast‐like cells toward proliferation." @default.
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• W2061037159 date "1989-01-30" @default.
• W2061037159 modified "2023-10-14" @default.
• W2061037159 title "Possible involvement of protein kinase C in proliferation and differentiation of osteoblast-like cells" @default.
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• W2061037159 doi "https://doi.org/10.1016/0014-5793(89)80126-7" @default.
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