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- W2061037897 abstract "Protein synthetic activity of anterior hypothalamic and neocortical brain slices from androgenized neonatal female rats was studied in vitro in an attempt to clarify the mechanism of action of testosterone on the developing hypothalamus. The short-term effects of testosterone propionate injections of the animals on the protein synthetic activity of the slices were assayed by means of incorporation of 14C-leucine into acid-insoluble protein. Although a high dose (1 mg/animal) of testosterone propionate stimulated increased incorporation in neocortical and anterior hypothalamic slices, a lower dose and other approaches failed to demonstrate a stimulation regionally specific to the anterior hypothalamus. It is concluded that if testosterone has specific stimulatory effects on protein synthesis in the anterior hypothalamus of neonatally androgenized rats, these are not readily demonstrable by methods used with other steroid target tissues." @default.
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- W2061037897 date "1979-01-01" @default.
- W2061037897 modified "2023-09-23" @default.
- W2061037897 title "Androgens and Brain Differentiation" @default.
- W2061037897 doi "https://doi.org/10.1159/000112449" @default.
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