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- W2061039215 abstract "The effects of sigma ligand haloperidol in the multicellularguinea pig heart preparations were examined. Adult male guineapigs were used. Left atrium and papillary muscle from rightventricle were examined. The stimulated twiches in horizontalbath were recorded isometrically. Sigma ligand haloperidol(10nM) was administered for 30 minutes. Its effect on theamplitude of contraction and on the mechanical restitution wasevaluated. Marked positive inotropic effect (increase in thetwitch amplitude ranging from 50 to 90 % for atria and 5 to 45%for ventricles, with maximal effect in the 5th minute of ligandadministration for both preparations) has been observed. Themechanical restitution pattern under the effect of sigmareceptor ligand is not altered. Thus, the positive inotropiceffect of haloperidol was confirmed in guinea pig heartpreparations. According to its effect on the mechanicalrestitution can be assumed that it is mediated via increasedcytoplasmatic calcium concentration." @default.
- W2061039215 created "2016-06-24" @default.
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- W2061039215 date "2002-06-01" @default.
- W2061039215 modified "2023-09-25" @default.
- W2061039215 title "Effect of sigma ligand haloperidol in guinea pig heart preparations" @default.
- W2061039215 doi "https://doi.org/10.1016/s0022-2828(02)91039-4" @default.
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